The “AT-hook” is a peculiar DNA-binding domain that interacts with DNA in the minor groove
in correspondence to AT-rich sequences. This domain has been first described in the HMGA …

Human 53BP1 is primarily known as a key player in regulating DNA double strand break
(DSB) repair choice; however, its involvement in other biological process is less well …

Simple Summary The gene encoding for the epigenetic regulator ATRX is gaining a
prominent position among the most important oncosuppressive genes of the human …

Successful approaches for eradication or cure of HIV-1 infection are likely to include
immunological mechanisms, but remarkably little is known about how human immune …

Pericentric heterochromatin (PCH) plays an essential role in the maintenance of genome
integrity and alterations in PCH have been linked to cancer and aging. HP1 α, β, and γ, are …

Aging-related diseases such as cancer can be traced to the accumulation of molecular
disorder including increased DNA mutations and epigenetic drift. We provide a …

Pericentromeric heterochromatin is mainly composed of satellite DNA sequences. Although
being historically associated with transcriptional repression, some pericentromeric satellite …

Rett syndrome (RTT, online MIM 312750) is a devastating neurodevelopmental disorder
characterized by motor and cognitive disabilities. It is mainly caused by pathogenetic …

Rett syndrome (RTT) is an extremely invalidating, cureless, developmental disorder, and it is
considered one of the leading causes of intellectual disability in female individuals. The vast …

Summary Methyl-CpG binding protein 2 (MeCP2) has historically been linked to
heterochromatin organization, and in mouse cells it accumulates at pericentric …