Assessment of the immune response to tumors is growing in importance as the prognostic
implications of this response are increasingly recognized, and as immunotherapies are …

Epithelial growth factor receptor (EGFR) is a cell surface transmembrane receptor that
mediates the tyrosine signaling pathway to carry the extracellular messages inside the cell …

Efforts to reduce global cancer disparities begin with an understanding of geographic
patterns in cancer incidence, mortality, and prevalence. Using the GLOBOCAN (2002) and …

Breast cancer is a heterogeneous disease, divisible into a variable number of clinical
subtypes. A fundamental question is how many etiological classes underlie the clinical …

The discovery of the first gene associated with hereditary breast cancer, BRCA1, was
anticipated to greatly increase our understanding of both hereditary and sporadic forms of …

Background Women genetically predisposed to breast cancer often develop the disease at a
young age when dense breast tissue reduces the sensitivity of X-ray mammography. Our …

PURPOSE: The morphologic and molecular phenotype of breast cancers may help identify
patients who are likely to carry germline mutations in BRCA1 and BRCA2. This study …

Background Many cases of hereditary breast cancer are due to mutations in either the
BRCA1 or the BRCA2 gene. The histopathological changes in these cancers are often …

Genetic and lifestyle/environmental factors are implicated in the aetiology of breast cancer.
This review summarizes the current state of knowledge on rare high penetrance mutations …

Purpose: To investigate the proportion of breast cancers arising in patients with germ line
BRCA1 and BRCA2 mutations expressing basal markers and developing predictive tests for …