Brain metastases affect a significant percentage of patients with advanced extracranial
malignancies. Yet, the incidence of brain metastases remains poorly described, largely due …

Immortal time bias is a problem arising from methodologically wrong analyses of time‐
dependent events in survival analyses. We illustrate the problem by analysis of a kidney …

Rationale & Objective Renin-angiotensin-aldosterone system (RAAS) inhibitors are
evidence-based therapies that slow the progression of chronic kidney disease (CKD) but …

Purpose To examine practice patterns and compare survival outcomes between total
laryngectomy (TL) and larynx preservation chemoradiation (LP-CRT) in the setting of T4a …

Importance Researchers often analyze cancer registry data to assess for differences in
survival among cancer treatments. However, the retrospective, nonrandomized design of …

Purpose To review trends in the use of postoperative radiotherapy (PORT) for stage II and III
incompletely resected non–small-cell lung cancer (NSCLC) and evaluate the association …

Importance Data on adjuvant concurrent chemoradiotherapy (CRT) after resection of
salivary gland carcinomas (SGCs) are limited. Objective To examine overall survival (OS) …

Background Following neoadjuvant chemotherapy (NAC), the optimal strategies for
postmastectomy radiotherapy (PMRT) and regional nodal irradiation (RNI) after breast …

The objectives of this study are to illustrate the effects of immortal time bias (ITB) using an
oncology outcomes database and quantify through simulations the magnitude and direction …

Background For node-positive vulvar cancer, adjuvant radiotherapy has an established
benefit, whereas the impact of chemotherapy is unknown. A National Cancer Data Base …