Betulinic acid and its derivatives as potential antitumor agents
Betulinic acid (BA) is a lupane‐type pentacyclic triterpene, distributed ubiquitously
throughout the plant kingdom. BA and its derivatives demonstrate multiple bioactivities …
throughout the plant kingdom. BA and its derivatives demonstrate multiple bioactivities …
The role of ABC transporters in ovarian cancer progression and chemoresistance
Over 80% of ovarian cancer patients develop chemoresistance which results in a lethal
course of the disease. A well-established cause of chemoresistance involves the family of …
course of the disease. A well-established cause of chemoresistance involves the family of …
Development of fourth generation ABC inhibitors from natural products: a novel approach to overcome cancer multidrug resistance
S Karthikeyan… - Anti-Cancer Agents in …, 2015 - ingentaconnect.com
Multidrug resistance (MDR) in cancer caused due to overexpression of ABC drug
transporters is a major problem in modern chemotherapy. Molecular investigations on MDR …
transporters is a major problem in modern chemotherapy. Molecular investigations on MDR …
Overcome cancer cell drug resistance using natural products
P Wang, HL Yang, YJ Yang, L Wang… - Evidence‐based …, 2015 - Wiley Online Library
Chemotherapy is one of the major treatment methods for cancer. However, failure in
chemotherapy is not uncommon, mainly due to dose‐limiting toxicity associated with drug …
chemotherapy is not uncommon, mainly due to dose‐limiting toxicity associated with drug …
Overcoming multidrug resistance: flavonoid and terpenoid nitrogen-containing derivatives as ABC transporter modulators
Multidrug resistance (MDR) in cancer is one of the main limitations for chemotherapy
success. Numerous mechanisms are behind the MDR phenomenon wherein the …
success. Numerous mechanisms are behind the MDR phenomenon wherein the …
Molecular bases of the poor response of liver cancer to chemotherapy
A characteristic shared by most frequent types of primary liver cancer, ie, hepatocellular
carcinoma (HCC) and cholangiocarcinoma (CCA) in adults, and in a lesser extent …
carcinoma (HCC) and cholangiocarcinoma (CCA) in adults, and in a lesser extent …
Discovery of a novel EGFR ligand DPBA that degrades EGFR and suppresses EGFR-positive NSCLC growth
Epidermal growth factor receptor (EGFR) activation plays a pivotal role in EGFR-driven non-
small cell lung cancer (NSCLC) and is considered as a key target of molecular targeted …
small cell lung cancer (NSCLC) and is considered as a key target of molecular targeted …
Triterpenoids as reversal agents for anticancer drug resistance treatment
XJ Yan, LH Gong, FY Zheng, KJ Cheng, ZS Chen… - Drug Discovery …, 2014 - Elsevier
Highlights•Triterpenoids work as reversal agents for anticancer drug resistance
treatment.•The chemical and anticancer properties of triterpenoids are introduced here.•The …
treatment.•The chemical and anticancer properties of triterpenoids are introduced here.•The …
Multiple molecular targets in breast cancer therapy by betulinic acid
R Luo, D Fang, P Chu, H Wu, Z Zhang… - Biomedicine & …, 2016 - Elsevier
Breast cancer is the second most common type of cancer in the world, and is by far the most
prevalent form of cancer in women. However, the efficacy of current treatments for breast …
prevalent form of cancer in women. However, the efficacy of current treatments for breast …
Discovery of new monocarbonyl ligustrazine–curcumin hybrids for intervention of drug-sensitive and drug-resistant lung cancer
Y Ai, B Zhu, C Ren, F Kang, J Li, Z Huang… - Journal of medicinal …, 2016 - ACS Publications
The elevation of oxidative stress preferentially in cancer cells by inhibiting thioredoxin
reductase (TrxR) and/or enhancing reactive oxygen species (ROS) production has emerged …
reductase (TrxR) and/or enhancing reactive oxygen species (ROS) production has emerged …