The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …

Atrial fibrillation (AF) is the most common cardiac arrhythmia despite substantial efforts to
understand the pathophysiology of the condition and develop improved treatments …

Reduced expression and/or activity of Kv1. 5 channels (encoded by KCNA5) is a common
hallmark in human or experimental pulmonary arterial hypertension (PAH). Likewise …

Atria-selective antiarrhythmic drugs in need of alliance partners. Guideline-based treatment
of atrial fibrillation (AF) comprises prevention of thromboembolism and stroke, as well as …

The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …

Previous studies have linked dysfunctional I to arising from mutations to KCND3-encoded
Kv4. 3 and KCND2-encoded Kv4. 2 to atrial fibrillation. Using computational models, this …

Introduction Atrial fibrillation (AF) is an increasingly prevalent and significant worldwide
health problem. Manifested as an irregular atrial electrophysiological activation, it is …

Atrial fibrillation (AF) is the most common cardiac arrhythmia. About 5–15% of AF patients
have a mutation in a cardiac gene, including mutations in KCNA5, encoding the Kv1. 5 α …

Atrial fibrillation is a common cardiac arrhythmia with an increasing incidence rate.
Particularly for the aging population, understanding the underlying mechanisms of atrial …

As a potentially life threatening side effect, pharmaceutical compounds may trigger cardiac
arrhythmias by impeding the heart's electrical and mechanical function. For this reason, any …