Prior to the SARS-CoV-2 pandemic, antibiotic resistance was listed as the major global
health care priority. Some analyses, including the O'Neill report, have predicted that deaths …

Candida albicans is a major fungal pathogen of humans. It exists as a commensal in the oral
cavity, gut or genital tract of most individuals, constrained by the local microbiota, epithelial …

Systemic fungal infections pose a serious clinical problem. Treatment options are limited,
and antifungal drug resistance is increasing. In addition, a substantial proportion of patients …

Candidiasis can be present as a cutaneous, mucosal or deep-seated organ infection, which
is caused by more than 20 types of Candida sp., with C. albicans being the most common …

In the past decade, advances in genome sequencing have allowed researchers to uncover
the history of hybridization in diverse groups of species, including our own. Although the …

The fungal pathogens Candida albicans, Cryptococcus neoformans, and Aspergillus
fumigatus have transitioned from a rare curiosity to a leading cause of human mortality. The …

Fungal infections, such as candidiasis caused by Candida, pose a problem of growing
medical concern. In developed countries, the incidence of Candida infections is increasing …

Ergosterol (ERG) is a critical sterol in the cell membranes of fungi, and its biosynthesis is
tightly regulated by 25 known enzymes along the ERG production pathway. The effects of …

Previously, we identified long repeat sequences that are frequently associated with genome
rearrangements, including copy number variation (CNV), in many diverse isolates of the …

Candida auris has emerged as a multidrug-resistant pathogen of great clinical concern.
Approximately 90% of clinical C. auris isolates are resistant to fluconazole, the most …