Genetic risk for autism spectrum disorder (ASD) is associated with hundreds of genes
spanning a wide range of biological functions,,,,–. The alterations in the human brain …

Abstract miRNet is an easy-to-use, web-based platform designed to help elucidate
microRNA (miRNA) functions by integrating users' data with existing knowledge via network …

The growing application of gene expression profiling demands powerful yet user-friendly
bioinformatics tools to support systems-level data understanding. NetworkAnalyst was first …

Researchers are increasingly seeking to interpret molecular data within a multi-omics
context to gain a more comprehensive picture of their study system. OmicsNet (www …

Molecular interaction networks lay the foundation for studying how biological functions are
controlled by the complex interplay of genes and proteins. Investigating perturbed processes …

Network-based approach is rapidly emerging as a promising strategy to integrate and
interpret different-omics datasets, including metabolomics. The first section of this chapter …

The circulating metabolome provides unique insights into multiple sclerosis (MS)
pathophysiology, but existing studies are relatively small or characterized limited …

A proper understanding of disease etiology will require longitudinal systems-scale
reconstruction of the multitiered architecture of eukaryotic signaling. Here we combine state …

The network approach is quickly becoming a fundamental building block of computational
methods aiming at elucidating the mechanism of action (MoA) and therapeutic effect of …

Biological systems are composed of a vast web of multiscale molecular interactors and
interactions. High-throughput technologies, both bulk and single cell, now allow for …