[HTML][HTML] Nanocarriers for pancreatic cancer imaging, treatments, and immunotherapies

L Liu, PG Kshirsagar, SK Gautam, M Gulati, EI Wafa… - Theranostics, 2022 - ncbi.nlm.nih.gov
Pancreatic tumors are highly desmoplastic and immunosuppressive. Delivery and
distribution of drugs within pancreatic tumors are compromised due to intrinsic physical and …

Nanomaterials for therapeutic RNA delivery

X Han, MJ Mitchell, G Nie - Matter, 2020 - cell.com
Recent years have witnessed tremendous developments and breakthroughs in the field of
RNA-based therapeutics. The distinct mechanisms of exogenous RNAs and analogs …

A bimetallic metal–organic framework encapsulated with DNAzyme for intracellular drug synthesis and self‐sufficient gene therapy

Z Wang, J Niu, C Zhao, X Wang, J Ren… - Angewandte …, 2021 - Wiley Online Library
Although chemotherapy is one of the most widely used cancer treatments, there are serious
side effects, drug resistance, and secondary metastasis. To address these problems, herein …

Targeting pulmonary tumor microenvironment with CXCR4-inhibiting nanocomplex to enhance anti–PD-L1 immunotherapy

Z Li, Y Wang, Y Shen, C Qian, D Oupicky, M Sun - Science advances, 2020 - science.org
Anti–programmed cell death 1 ligand 1 (PD-L1) therapy is extraordinarily effective in select
patients with cancer. However, insufficient lymphocytic infiltration, weak T cell–induced …

Stromal modulation and treatment of metastatic pancreatic cancer with local intraperitoneal triple miRNA/siRNA nanotherapy

Y Xie, Y Hang, Y Wang, R Sleightholm, DR Prajapati… - ACS …, 2020 - ACS Publications
Nanomedicines achieve tumor-targeted delivery mainly through enhanced permeability and
retention (EPR) effect following intravenous (IV) administration. Unfortunately, the EPR effect …

Recent advances in delivery of drug–nucleic acid combinations for cancer treatment

J Li, Y Wang, Y Zhu, D Oupický - Journal of controlled release, 2013 - Elsevier
Cancer treatment that uses a combination of approaches with the ability to affect multiple
disease pathways has been proven highly effective in the treatment of many cancers …

High DNA‐binding affinity and gene‐transfection efficacy of bioreducible cationic nanomicelles with a fluorinated core

LH Wang, DC Wu, HX Xu, YZ You - Angewandte Chemie, 2016 - Wiley Online Library
During the last two decades, cationic polymers have become one of the most promising
synthetic vectors for gene transfection. However, the weak interactions formed between DNA …

Modified chitosan for effective renal delivery of siRNA to treat acute kidney injury

W Tang, S Panja, CM Jogdeo, S Tang, L Ding, A Yu… - Biomaterials, 2022 - Elsevier
Acute kidney injury (AKI) is characterized by a sudden decrease in renal function and
impacts growing number of people worldwide. RNA interference (RNAi) showed potential to …

Thrombin-responsive, brain-targeting nanoparticles for improved stroke therapy

X Guo, G Deng, J Liu, P Zou, F Du, F Liu, AT Chen… - ACS …, 2018 - ACS Publications
Current treatments for ischemic stroke are insufficient. The lack of effective pharmacological
approaches can be mainly attributed to the difficulty in overcoming the blood–brain barrier …

Perspectives about self-immolative drug delivery systems

RV Gonzaga, LA do Nascimento, SS Santos… - Journal of …, 2020 - Elsevier
Self-immolative drug delivery system is one of the delivery systems, which have drawn
attention, in recent research, highlighting the improvement they generate in drug selectivity …