Research over the past decade has extended the prevailing view of the mitochondrion to
include functions well beyond the generation of cellular energy. It is now recognized that …

Alzheimer's disease (AD) is an age-related neurodegenerative disorder. Although an
accumulation of brain amyloid-β (Aβ) peptide and hyperphosphorylated tau protein have …

The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …

VDAC1 is found at the crossroads of metabolic and survival pathways. VDAC1 controls
metabolic cross-talk between mitochondria and the rest of the cell by allowing the influx and …

Research over the last decade has extended the prevailing view of mitochondria to include
functions well beyond the critical bioenergetics role in supplying ATP. It is now recognized …

In brain and tumor cells, the hexokinase isoforms HK-I and HK-II bind to the voltage-
dependent anion channel (VDAC) in the outer mitochondrial membrane. We have …

The release of mitochondrial-intermembrane-space pro-apoptotic proteins, such as
cytochrome c, is a key step in initiating apoptosis. Our study addresses two major questions …

Here, we review current evidence pointing to the function of VDAC1 in cell life and death,
and highlight these functions in relation to cancer. Found at the outer mitochondrial …

In the outer mitochondrial membrane, the voltage-dependent anion channel 1 (VDAC1)
functions in cellular Ca2+ homeostasis by mediating the transport of Ca2+ in and out of …

Cancer cells share several properties, high proliferation potential, reprogramed metabolism,
and resistance to apoptotic cues. Acquiring these hallmarks involves changes in key …