Abstract Purpose of Review Leptomeningeal disease (LMD) is a rare, late complication of
systemic cancer and is associated with significant neurological morbidity and high mortality …

The blood–brain barrier (BBB) plays an important protective role in the central nervous
system and maintains its homeostasis. It regulates transport into brain tissue and protects …

Striking similarity exists between metabolic changes associated with embryogenesis and
tumorigenesis. Chromobox proteins‐CBX2/4/6/7/8, core components of canonical polycomb …

Purpose Breast cancer is a common malignancy in women, and its metastasis is a leading
cause of cancer-related deaths. Single-cell RNA sequencing (scRNA-seq) can distinguish …

Simple Summary HER2-positive breast cancer has an affinity for the central nervous system
(CNS) manifested by metastases in both the brain parenchyma and the leptomeninges. The …

Despite a relatively low prevalence of primary brain tumors, they continuously attract
scientific interest because of the complexity of their treatment due to their location behind the …

Adjuvant treatment for Glioblastoma Grade 4 with Temozolomide (TMZ) inevitably fails due
to therapeutic resistance, necessitating new approaches. Apoptosis induction in GB cells is …

Leptomeningeal disease (LMD) is a devastating sequelae of metastatic spread that affects
approximately 5% of cancer patients. The incidence of LMD is increasing due to …

Breast cancer is the most frequent malignancy in women. However, in the middle and late
stages, some people develop distant metastases, which considerably lower the quality of life …

Breast cancer is one of the most common malignancies among women worldwide.
According to the International Agency for Research on Cancer, breast cancer affected more …