In the last few years there has been a veritable explosion of knowledge about cyclic
nucleotide phosphodiesterases. In particular, the accumulating data showing that there are …

cAMP is a second messenger that controls many key cellular functions. The only way to
inactivate cAMP is to degrade it through the action of cAMP phosphodiesterases (PDEs) …

Microtubule-dependent motor, murine KIF3B, was disrupted by gene targeting. The null
mutants did not survive beyond midgestation, exhibiting growth retardation, pericardial sac …

Substantial insight has recently been achieved into the mechanisms responsible for the
generation of left–right (L–R) asymmetry in the vertebrate body plan,,,. However, the …

Catecholamines signal through the β2-adrenergic receptor by promoting production of the
second messenger adenosine 3′, 5′-monophosphate (cAMP). The magnitude of this …

Four decades have passed since Sutherland and Rall (1) reported the presence of cyclic
nucleotide hydrolyzing activity in extracts of a variety of tissues. This enzymatic activity …

A cAMP-specific phosphodiesterase (PDE4D3) is activated in rat thyroid cells by TSH
through a cAMP-dependent phosphorylation (Sette, C., Iona, S., and Conti, M.(1994) J. Biol …

Recent progress in the field of cyclic nucleotidos has shown that a large array of closely
related proteins is involved in each step of the signal transduction cascade. Nine families of …

Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated
phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1) - PMC …

The WD-repeat protein receptor for activated C-kinase (RACK1) was identified by its
interaction with the cyclic AMP-specific phosphodiesterase (PDE4) isoform PDE4D5 in a …