Over the past 30 years, several cross-species transmission events, as well as changes in
virus tropism, have mediated significant animal and human diseases. Most notable is severe …

Fundamental cellular operations, including DNA synthesis and the generation of ATP,
require iron. Viruses hijack cells in order to replicate, and efficient replication needs an iron …

Plasmodium vivax shows a strict host tropism for reticulocytes. We identified transferrin
receptor 1 (TfR1) as the receptor for P. vivax reticulocyte-binding protein 2b (PvRBP2b). We …

Because both the host and pathogen require iron, the innate immune response carefully
orchestrates control over iron metabolism to limit its availability during times of infection …

Hepatitis C virus (HCV) is a liver tropic pathogen that affects∼ 170 million people worldwide
and causes liver pathologies including fibrosis, cirrhosis, steatosis, iron overload, and …

Abstract Human transferrin receptor 1 (CD71) guarantees iron supply by endocytosis upon
binding of iron-loaded transferrin and ferritin. Arenaviruses and the malaria parasite exploit …

Biological factors that influence the host range and spillover of Ebola virus (EBOV) and other
filoviruses remain enigmatic. While filoviruses infect diverse mammalian cell lines, we report …

Arenavirus pathogens cause a wide spectrum of diseases in humans ranging from central
nervous system disease to lethal hemorrhagic fevers with few treatment options. The reason …

Arenaviruses comprise a diverse family of enveloped negative-strand RNA viruses that are
endemic to specific rodent hosts worldwide. Several arenaviruses cause severe …

New World hemorrhagic fever arenaviruses are rodent-borne agents that cause severe
human disease. The GP1 subunit of the surface glycoprotein mediates cell attachment …