Digital twins for tissue culture techniques—concepts, expectations, and state of the art

J Möller, R Pörtner - Processes, 2021 - mdpi.com
Techniques to provide in vitro tissue culture have undergone significant changes during the
last decades, and current applications involve interactions of cells and organoids, three …

Bioengineering of bone tissues using bioreactors for modulation of mechano-sensitivity in bone

Darshna, R Kumar, P Srivastava… - … and Genetic Engineering …, 2023 - Taylor & Francis
Since the last decade, significant developments have been made in the area of bone tissue
engineering associated with the emergence of novel biomaterials as well as techniques of …

Temperature distribution assessment in gas–solid reactive and nonreactive systems heated by microwaves

K Adavi, J Shabanian, J Chaouki - Industrial & Engineering …, 2023 - ACS Publications
Research studies have shown that selective heating of different phases in gas–solid
systems exposed to microwave (MW) irradiation leads to a temperature gradient between …

Optimization and validation of a custom-designed perfusion bioreactor for bone tissue engineering: Flow assessment and optimal culture environmental conditions

S Yamada, MA Yassin, T Schwarz, K Mustafa… - … in Bioengineering and …, 2022 - frontiersin.org
Various perfusion bioreactor systems have been designed to improve cell culture with three-
dimensional porous scaffolds, and there is some evidence that fluid force improves the …

[HTML][HTML] Cell-based modeling of tissue developing in the scaffold pores of varying cross-sections

I Krasnyakov, D Bratsun - Biomimetics, 2023 - mdpi.com
In this work, we present a mathematical model of cell growth in the pores of a perfusion
bioreactor through which a nutrient solution is pumped. We have developed a 2-D vertex …

Construction of spider silk protein small‐caliber tissue engineering vascular grafts based on dynamic culture and its performance evaluation

L Sun, X Li, T Yang, T Lu, P Du, C Jing… - … Research Part A, 2023 - Wiley Online Library
Tissue engineering is an alternative method for preparing small‐caliber (< 6 mm) vascular
grafts. Dynamic mechanical conditioning is being researched as a method to improve …

A critical aspect of bioreactor designing and its application for the generation of tissue engineered construct: Emphasis on clinical translation of bioreactor

A Anand, SP Mallick, BN Singh, S Kumari… - Biotechnology and …, 2022 - Springer
Usage of bioreactors in the field of tissue engineering has played a significant role in
enabling a controlled and reproducible change in the formation of damaged tissue on being …

Pre-vascularized porous gelatin-coated β-tricalcium phosphate scaffolds for bone regeneration: an in vivo and in vitro investigation

H Nokhbatolfoghahaei, S Baniameri, R Tabrizi… - In Vitro Cellular & …, 2024 - Springer
Vascularization is vital in bone tissue engineering, supporting development, remodeling,
and regeneration. Lack of vascularity leads to cell death, necessitating vascularization …

Global sensitivity analysis for a perfusion bioreactor based on CFD modelling

I Nașcu, D Sebastia-Saez, T Chen, I Nașcu… - Computers & chemical …, 2022 - Elsevier
Perfusion bioreactors are important tools in tissue engineering that are used for cell
cultivation. Unfortunately these types of processes are not yet fully understood in literature …

Perfused platforms to mimic bone microenvironment at the macro/milli/microscale: pros and cons

MV Lipreri, N Baldini, G Graziani… - Frontiers in Cell and …, 2022 - frontiersin.org
As life expectancy increases, the population experiences progressive ageing. Ageing, in
turn, is connected to an increase in bone-related diseases (ie, osteoporosis and increased …