Near-infrared luminescence high-contrast in vivo biomedical imaging

Y Chen, S Wang, F Zhang - Nature Reviews Bioengineering, 2023 - nature.com
Luminescence imaging in biomedical research has allowed new insights into the
architecture of pathological tissues, signalling networks and cell interactions, and is now …

Molecular probes for autofluorescence-free optical imaging

Y Jiang, K Pu - Chemical reviews, 2021 - ACS Publications
Optical imaging is an indispensable tool in clinical diagnostics and fundamental biomedical
research. Autofluorescence-free optical imaging, which eliminates real-time optical …

Determination of tumor margins with surgical specimen mapping using near-infrared fluorescence

RW Gao, NT Teraphongphom, NS van den Berg… - Cancer research, 2018 - AACR
For many solid tumors, surgical resection remains the gold standard and tumor-involved
margins are associated with poor clinical outcomes. Near-infrared (NIR) fluorescence …

Review of methods for intraoperative margin detection for breast conserving surgery

BW Maloney, DM McClatchy, BW Pogue… - … of biomedical optics, 2018 - spiedigitallibrary.org
Breast conserving surgery (BCS) is an effective treatment for early-stage cancers as long as
the margins of the resected tissue are free of disease according to consensus guidelines for …

Prospective testing of clinical Cerenkov luminescence imaging against standard-of-care nuclear imaging for tumour location

EC Pratt, M Skubal, B Mc Larney… - Nature biomedical …, 2022 - nature.com
In oncology, the feasibility of Cerenkov luminescence imaging (CLI) has been assessed by
imaging superficial lymph nodes in a few patients undergoing diagnostic 18F-fluoro-2 …

Optical imaging modalities: principles and applications in preclinical research and clinical settings

G Pirovano, S Roberts, S Kossatz… - Journal of Nuclear …, 2020 - Soc Nuclear Med
With the ability to noninvasively image and monitor molecular processes within tumors,
molecular imaging represents a fundamental tool for cancer scientists. In the current review …

Intraoperative detection and eradication of residual microtumors with gap-enhanced Raman tags

Y Qiu, Y Zhang, M Li, G Chen, C Fan, K Cui, JB Wan… - ACS …, 2018 - ACS Publications
The inability to intraoperatively diagnose and eliminate microscopic residual tumors
represents a significant challenge in cancer surgery. These residual microtumors cause …

Intraoperative fluorescence molecular imaging accelerates the coming of precision surgery in China

Z Zhang, K He, C Chi, Z Hu, J Tian - European Journal of Nuclear Medicine …, 2022 - Springer
Purpose China has the largest cancer population globally. Surgery is the main choice for
most solid cancer patients. Intraoperative fluorescence molecular imaging (FMI) has shown …

Emerging intraoperative imaging modalities to improve surgical precision

IS Alam, I Steinberg, O Vermesh… - Molecular Imaging and …, 2018 - Springer
Intraoperative imaging (IOI) is performed to guide delineation and localization of regions of
surgical interest. While oncological surgical planning predominantly utilizes x-ray computed …

Activating TiO2 Nanoparticles: Gallium-68 Serves as a High-Yield Photon Emitter for Cerenkov-Induced Photodynamic Therapy

D Duan, H Liu, Y Xu, Y Han, M Xu… - ACS applied materials …, 2018 - ACS Publications
The classical photodynamic therapy (PDT) requires external light to activate
photosensitizers for cancer treatment. However, limited tissue penetration of light has been a …