A substantial fraction of eukaryotic gene products are synthesized by ribosomes attached at
the cytosolic face of the endoplasmic reticulum (ER) membrane. These polypeptides enter …

Anthrax toxin consists of three nontoxic proteins that self-assemble at the surface of receptor-
bearing mammalian cells or in solution, yielding a series of toxic complexes. Two of the …

Generalized gingival enlargement can be caused by a variety of etiological factors. It can be
inherited (hereditary gingival fibromatosis [HGF]); associated with other diseases …

Anthrax toxin, a major virulence factor of Bacillus anthracis, gains entry into target cells by
binding to either of 2 von Willebrand factor A domain-containing proteins, tumor endothelium …

Modern technological innovations have advanced our understanding of the genetic basis of
spondyloarthritis. In ankylosing spondylitis (AS), where the major histocompatibility complex …

The past five years have led to a tremendous increase in our molecular understanding of the
mode of action of the anthrax toxin, one of the two main virulence factors produced by …

Loss-of-function mutations in capillary morphogenesis gene 2 (CMG2/ANTXR2), a
transmembrane surface protein, cause hyaline fibromatosis syndrome (HFS), a severe …

Disorders of Connective Tissue Page 1 CHAPTER 45 Disorders of Connective Tissue NP
Burrows1 & CR Lovell2 1Department of Dermatology, Addenbrooke’s Hospital, Cambridge …

Anthrax toxin is released from Bacillus anthracis as three monomeric proteins, which
assemble into toxic complexes at the surface of receptor-bearing host cells. One of the …

Fibroblastic and myofibroblastic tumors in children and adolescents are a relatively common
group of soft tissue proliferations that range from reactive to hamartomatous to neoplastic …