Pyruvate kinase plays a pivotal role in regulating cell metabolism. The final and rate-limiting
step of glycolysis is the conversion of Phosphoenolpyruvate (PEP) to Pyruvate, which is …

Metabolism and gene expression, which are two fundamental biological processes that are
essential to all living organisms, reciprocally regulate each other to maintain homeostasis …

High expression of PD-L1 in tumor cells contributes to tumor immune evasion. However,
whether PD-L1 expression in tumor cells is regulated by the availability of nutrients is …

Key pathological, including oncogenic, signaling pathways regulate the canonical functions
of metabolic enzymes that serve the cellular metabolic needs. Importantly, these signaling …

Glioblastoma multiforme (GBM) is the most common form of brain cancer and one of the
most aggressive cancers found in humans. Most of the signs and symptoms of GBM can be …

Gene transcription and cell metabolism are two fundamental biological processes that
mutually regulate each other. Upregulated or altered expression of glucose metabolic genes …

Pyruvate kinase (PK), as one of the key enzymes for glycolysis, can encode four different
subtypes from two groups of genes, although the M2 subtype PKM2 is expressed mainly …

Oxygen availability, along with the abundance of nutrients (such as glucose, glutamine,
lipids and albumin), fluctuates significantly during tumour evolution and the recruitment of …

Increasing evidence suggests the important role of metabolic reprogramming in the
regulation of the innate inflammatory response, but the underlying mechanism remains …

As tumours evolve, the daughter cells of the initiating cell often become molecularly
heterogeneous and develop different functional properties and therapeutic vulnerabilities. In …