Lipoxygenase (5-LOX) catalyzes two steps in the biosynthesis of leukotrienes (LTs), lipid
mediators of inflammation derived from arachidonic acid. In this review we focus on 5-LOX …

Metabolism of arachidonic acid leads to several families of lipid mediators, including
prostaglandins, thromboxane, leukotrienes, and lipoxins, along two major metabolic …

The ability to control cell volume is pivotal for cell function. Cell volume perturbation elicits a
wide array of signaling events, leading to protective (eg, cytoskeletal rearrangement) and …

5-Lipoxygenase (5-LO) catalyzes the first two steps in the biosynthesis of leukotrienes, a
group of pro-inflammatory lipid mediators derived from arachidonic acid. Leukotriene …

The reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase is part of the
microbicidal arsenal used by human polymorphonuclear neutrophils (PMNs) to eradicate …

Leukotrienes are powerful immune-regulating lipid mediators with established pathogenic
roles in inflammatory allergic diseases of the respiratory tract—in particular, asthma and hay …

Covering: primarily 1980 to 2008 This review, containing over 276 references, covers the
progress made in the chemistry and bioactivity of this important group of triterpenoids …

5-Lipoxygenase (5-LO) catalyzes the conversion of arachidonic acid (AA) into leukotriene
(LT) A4 and 5-hydroperoxyeicosatetraenoic acid. LTA4 can then be converted into LTB4 by …

The initial steps in the biosynthesis of leukotrienes from arachidonic acid are carried out by
the enzyme 5-lipoxygenase (5-LO). In intact cells, the helper protein 5-LO activating protein …

5-Lipoxygenase (5-LO) catalyzes two steps in biosynthesis of leukotrienes (LTs), a group of
lipid mediators of inflammation derived from arachidonic acid (AA). LT antagonists are used …