Improving cancer immunotherapy through nanotechnology
MS Goldberg - Nature Reviews Cancer, 2019 - nature.com
Abstract The 2018 Nobel Prize in Physiology or Medicine was awarded to pioneers in the
field of cancer immunotherapy, as the utility of leveraging a patient's coordinated and …
field of cancer immunotherapy, as the utility of leveraging a patient's coordinated and …
Polymeric micro-and nanoparticles for immune modulation
New advances in biomaterial-based approaches to modulate the immune system are being
applied to treat cancer, infectious diseases, and autoimmunity. Particulate systems are …
applied to treat cancer, infectious diseases, and autoimmunity. Particulate systems are …
Antibody–drug nanoparticle induces synergistic treatment efficacies in HER2 positive breast cancer cells
Chemotherapeutic drugs suffer from non-specific binding, undesired toxicity, and poor blood
circulation which contribute to poor therapeutic efficacy. In this study, antibody–drug …
circulation which contribute to poor therapeutic efficacy. In this study, antibody–drug …
Biodegradable cationic polymer blends for fabrication of enhanced artificial antigen presenting cells to treat melanoma
Biomimetic biomaterials are being actively explored in the context of cancer immunotherapy
because of their ability to directly engage the immune system to generate antitumor …
because of their ability to directly engage the immune system to generate antitumor …
Nanoparticles for generating antigen-specific T cells for immunotherapy
T cell therapy shows promise as an immunotherapy in both immunostimulatory and
immunosuppressive applications. However, the forms of T cell-based therapy that are …
immunosuppressive applications. However, the forms of T cell-based therapy that are …
Improvement of islet engrafts via Treg induction using immunomodulating polymeric tolerogenic microparticles
Type 1 diabetes (T1D) is a life-threatening condition for which islet transplantation offers a
way to extend longevity and vastly improve quality of life, but the degree and duration of …
way to extend longevity and vastly improve quality of life, but the degree and duration of …
In situ genetic engineering of tumors for long-lasting and systemic immunotherapy
Cancer immunotherapy has been the subject of extensive research, but highly effective and
broadly applicable methods remain elusive. Moreover, a general approach to engender …
broadly applicable methods remain elusive. Moreover, a general approach to engender …
3D bioprinting and translation of beta cell replacement therapies for type 1 diabetes
RE Gurlin, JA Giraldo, E Latres - Tissue Engineering Part B …, 2021 - liebertpub.com
Type 1 diabetes (T1D) is an autoimmune disorder in which the body's own immune system
selectively attacks beta cells within pancreatic islets resulting in insufficient insulin …
selectively attacks beta cells within pancreatic islets resulting in insufficient insulin …
Nanomedicine revisited: next generation therapies for brain cancer
AG Bhargav, SK Mondal, CA Garcia… - Advanced …, 2020 - Wiley Online Library
Brain cancer persists as a difficult‐to‐treat condition. In particular, metastatic brain cancer
and malignant primary brain tumors such as glioblastoma (GBM) are among the most deadly …
and malignant primary brain tumors such as glioblastoma (GBM) are among the most deadly …
3D Centrifugation‐Enabled Priming of Synaptic Activation Promotes Primary T Cell Expansion
Autologous cell therapy depends on T lymphocyte expansion efficiency and is hindered by
suboptimal interactions between T cell receptors (TCR) and peptide‐MHC molecules …
suboptimal interactions between T cell receptors (TCR) and peptide‐MHC molecules …