3′-end processing of eukaryotic mRNA: machinery, regulation, and impact on gene expression
V Boreikaitė, LA Passmore - Annual review of biochemistry, 2023 - annualreviews.org
Formation of the 3′ end of a eukaryotic mRNA is a key step in the production of a mature
transcript. This process is mediated by a number of protein factors that cleave the pre …
transcript. This process is mediated by a number of protein factors that cleave the pre …
Aberrant pre-mRNA processing in cancer
J Biswas, L Boussi, E Stein… - Journal of Experimental …, 2024 - rupress.org
Dysregulation of the flow of information from genomic DNA to RNA to protein occurs within
all cancer types. In this review, we described the current state of understanding of how RNA …
all cancer types. In this review, we described the current state of understanding of how RNA …
Elevated pre-mRNA 3′ end processing activity in cancer cells renders vulnerability to inhibition of cleavage and polyadenylation
Cleavage and polyadenylation (CPA) is responsible for 3′ end processing of eukaryotic
poly (A)+ RNAs and preludes transcriptional termination. JTE-607, which targets CPSF-73 …
poly (A)+ RNAs and preludes transcriptional termination. JTE-607, which targets CPSF-73 …
CPSF1 inhibition promotes widespread use of intergenic polyadenylation sites and impairs glycolysis in prostate cancer cells
KT Tietz, BM McCluskey, CR Miller, Y Li, SA Munro… - Cell reports, 2025 - cell.com
Localized prostate cancer can be cured by radiation or surgery, but advanced prostate
cancer continues to be a clinical challenge. Altered alternative polyadenylation occurs in …
cancer continues to be a clinical challenge. Altered alternative polyadenylation occurs in …
Alternative Polyadenylation in Cancer: Molecular Mechanisms and Clinical Application
Y Zhang, Z Huang, W Lu, Z Liu - Critical Reviews in Oncology/Hematology, 2024 - Elsevier
Alternative polyadenylation (APA) serves as a crucial mechanism for the posttranscriptional
regulation of gene expression and influences gene expression by generating diverse mRNA …
regulation of gene expression and influences gene expression by generating diverse mRNA …
Modulation of diverse biological processes by CPSF, the master regulator of mRNA 3′ ends
L Liu, JL Manley - RNA, 2024 - rnajournal.cshlp.org
The cleavage and polyadenylation specificity factor (CPSF) complex plays a central role in
the formation of mRNA 3′ ends, being responsible for the recognition of the poly (A) signal …
the formation of mRNA 3′ ends, being responsible for the recognition of the poly (A) signal …