The tumor microenvironment in tumorigenesis and therapy resistance revisited
Simple Summary Tumors are not masses of cancer cells alone but made up of cancer cells,
other cells including fibroblasts, macrophages, endothelial cells, as well as secreted factors …
other cells including fibroblasts, macrophages, endothelial cells, as well as secreted factors …
How many carbonic anhydrase inhibition mechanisms exist?
CT Supuran - Journal of enzyme inhibition and medicinal chemistry, 2016 - Taylor & Francis
Six genetic families of the enzyme carbonic anhydrase (CA, EC 4.2. 1.1) were described to
date. Inhibition of CAs has pharmacologic applications in the field of antiglaucoma …
date. Inhibition of CAs has pharmacologic applications in the field of antiglaucoma …
Genome-wide synthetic lethal screen unveils novel CAIX-NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors
The metabolic mechanisms involved in the survival of tumor cells within the hypoxic niche
remain unclear. We carried out a synthetic lethal CRISPR screen to identify survival …
remain unclear. We carried out a synthetic lethal CRISPR screen to identify survival …
Manipulating extracellular tumour pH: an effective target for cancer therapy
The pH in tumour cells and the tumour microenvironment has played important roles in
cancer development and treatment. It was thought that both the extracellular and …
cancer development and treatment. It was thought that both the extracellular and …
Nanomedicine strategies in conquering and utilizing the cancer hypoxia environment
Y Pan, L Liu, X Mou, Y Cai - ACS nano, 2023 - ACS Publications
Cancer with a complex pathological process is a major disease to human welfare. Due to
the imbalance between oxygen (O2) supply and consumption, hypoxia is a natural …
the imbalance between oxygen (O2) supply and consumption, hypoxia is a natural …
Recent progress in electrochemical pH-sensing materials and configurations for biomedical applications
pH-sensing materials and configurations are rapidly evolving toward exciting new
applications, especially those in biomedical applications. In this review, we highlight rapid …
applications, especially those in biomedical applications. In this review, we highlight rapid …
Interfering with pH regulation in tumours as a therapeutic strategy
D Neri, CT Supuran - Nature reviews Drug discovery, 2011 - nature.com
The high metabolic rate of tumours often leads to acidosis and hypoxia in poorly perfused
regions. Tumour cells have thus evolved the ability to function in a more acidic environment …
regions. Tumour cells have thus evolved the ability to function in a more acidic environment …
Amorphous Fe‐based nanoagents for self‐enhanced chemodynamic therapy by re‐establishing tumor acidosis
Chemodynamic therapy (CDT) by introducing the Fenton‐/Fenton‐like reaction in an acidic
and H2O2 environment for toxic hydroxyl radical (• OH) generation, is a newly developed …
and H2O2 environment for toxic hydroxyl radical (• OH) generation, is a newly developed …
A self‐assembled albumin‐based nanoprobe for in vivo ratiometric photoacoustic pH imaging
DOI: 10.1002/adma. 201503194 needed to develop an accurate and easy-to-operate
method for real-time in vivo noninvasive pH imaging. Different from fluorescence imaging …
method for real-time in vivo noninvasive pH imaging. Different from fluorescence imaging …
Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis
F Pacchiano, F Carta, PC McDonald… - Journal of medicinal …, 2011 - ACS Publications
A series of ureido-substituted benzenesulfonamides was prepared that showed a very
interesting profile for the inhibition of several human carbonic anhydrases (hCAs, EC 4.2 …
interesting profile for the inhibition of several human carbonic anhydrases (hCAs, EC 4.2 …