Drug combinations: a strategy to extend the life of antibiotics in the 21st century
Antimicrobial resistance threatens a resurgence of life-threatening bacterial infections and
the potential demise of many aspects of modern medicine. Despite intensive drug discovery …
the potential demise of many aspects of modern medicine. Despite intensive drug discovery …
Targeting the holy triangle of quorum sensing, biofilm formation, and antibiotic resistance in pathogenic bacteria
RV Sionov, D Steinberg - Microorganisms, 2022 - mdpi.com
Chronic and recurrent bacterial infections are frequently associated with the formation of
biofilms on biotic or abiotic materials that are composed of mono-or multi-species cultures of …
biofilms on biotic or abiotic materials that are composed of mono-or multi-species cultures of …
Extensive impact of non-antibiotic drugs on human gut bacteria
A few commonly used non-antibiotic drugs have recently been associated with changes in
gut microbiome composition, but the extent of this phenomenon is unknown. Here, we …
gut microbiome composition, but the extent of this phenomenon is unknown. Here, we …
Antibacterial drug discovery in the resistance era
The looming antibiotic-resistance crisis has penetrated the consciousness of clinicians,
researchers, policymakers, politicians and the public at large. The evolution and widespread …
researchers, policymakers, politicians and the public at large. The evolution and widespread …
Drug repurposing for antimicrobial discovery
Antimicrobial resistance continues to be a public threat on a global scale. The ongoing need
to develop new antimicrobial drugs that are effective against multi-drug-resistant pathogens …
to develop new antimicrobial drugs that are effective against multi-drug-resistant pathogens …
Systematic analysis of drug combinations against Gram-positive bacteria
Drug combinations can expand options for antibacterial therapies but have not been
systematically tested in Gram-positive species. We profiled~ 8,000 combinations of 65 …
systematically tested in Gram-positive species. We profiled~ 8,000 combinations of 65 …
[HTML][HTML] Drug repurposing for next-generation combination therapies against multidrug-resistant bacteria
Antimicrobial resistance has been a global health challenge that threatens our ability to
control and treat life-threatening bacterial infections. Despite ongoing efforts to identify new …
control and treat life-threatening bacterial infections. Despite ongoing efforts to identify new …
Antibiotic adjuvants: a versatile approach to combat antibiotic resistance
The problem of antibiotic resistance is on the rise, with multidrug-resistant strains emerging
even to the last resort antibiotics. The drug discovery process is often stalled by stringent cut …
even to the last resort antibiotics. The drug discovery process is often stalled by stringent cut …
Drug repurposing for the treatment of bacterial and fungal infections
A Miró-Canturri, R Ayerbe-Algaba… - Frontiers in microbiology, 2019 - frontiersin.org
Multidrug-resistant (MDR) pathogens pose a well-recognized global health threat that
demands effective solutions; the situation is deemed a global priority by the World Health …
demands effective solutions; the situation is deemed a global priority by the World Health …
Antibiotic resistant bacteria: current situation and treatment options to accelerate the development of a new antimicrobial arsenal
A Tarín-Pelló, B Suay-García… - Expert Review of Anti …, 2022 - Taylor & Francis
Introduction Antibiotic resistance is one of the biggest public health threats worldwide.
Currently, antibiotic-resistant bacteria kill 700,000 people every year. These data represent …
Currently, antibiotic-resistant bacteria kill 700,000 people every year. These data represent …