Abstracts Bone mainly functions as a supportive framework for the whole body and is the
major regulator of calcium homeostasis and hematopoietic function. Recently, an increasing …

Besides the classical ones (support/protection, hematopoiesis, storage for calcium, and
phosphate) multiple roles emerged for bone tissue, definitively making it an organ …

Obesity is caused by an imbalance between food intake and energy expenditure (EE). Here
we identify a conserved pathway that links signalling through peripheral Y1 receptors (Y1R) …

The rising incidence of metabolic diseases worldwide has prompted renewed interest in the
study of intermediary metabolism and cellular bioenergetics. The application of modern …

Preclinical studies demonstrated that bone plays a central role in energy metabolism.
However, how bone metabolism is related to the risk of diabetes in humans is unknown. We …

Excess caloric intake results in increased fat accumulation and an increase in energy
expenditure via diet-induced adaptive thermogenesis; however, the underlying mechanisms …

Objective The skeleton, which is strongly controlled by endocrine factors, has recently been
shown to also play an active endocrine role itself, specifically influencing energy …

Objective Aguti-related protein (AGRP) neurons in the arcuate nucleus of the hypothalamus
(ARC), which co-express neuropeptide Y (NPY), are key regulators of feeding and energy …

Biological processes utilize energy and therefore must be prioritized based on fuel
availability. Bone is no exception to this, and the benefit of remodeling when necessary …

Pancreatic β cells secrete insulin in response to glucose, a process that is regulated at
multiple levels, including a network of input signals from other organ systems. Impaired islet …