Cytogenetic biomarkers of radiation exposure

RM Anderson - Clinical Oncology, 2019 - Elsevier
Biological monitoring of radiation exposure relies heavily on the quantification of
chromosome aberrations such as dicentrics and reciprocal translocations in the peripheral …

Particles with similar LET values generate DNA breaks of different complexity and reparability: a high-resolution microscopy analysis of γH2AX/53BP1 foci

L Jezkova, M Zadneprianetc, E Kulikova, E Smirnova… - Nanoscale, 2018 - pubs.rsc.org
Biological effects of high-LET (linear energy transfer) radiation have received increasing
attention, particularly in the context of more efficient radiotherapy and space exploration …

Determining Omics Spatiotemporal Dimensions Using Exciting New Nanoscopy Techniques to Assess Complex Cell Responses to DNA Damage: Part B …

M Falk, M Hausmann, E Lukasova… - Critical Reviews™ in …, 2014 - dl.begellhouse.com
Recent groundbreaking developments in Omics and bioinformatics have generated new
hope for overcoming the complexity and variability of (radio) biological systems while …

Radiation track structure: how the spatial distribution of energy deposition drives biological response

MA Hill - Clinical Oncology, 2020 - Elsevier
Ionising radiation is incredibly effective at causing biological effects. This is due to the
unique way energy is deposited along highly structured tracks of ionisation and excitation …

Variation in RBE for survival of V79-4 cells as a function of alpha-particle (helium ion) energy

BL Tracy, DL Stevens, DT Goodhead… - Radiation …, 2015 - meridian.allenpress.com
High linear energy transfer (LET) α particles are important with respect to the carcinogenic
risk associated with human exposure to ionizing radiation, most notably to radon and its …

Effect of Linear Energy Transfer (LET) on the Complexity of α-Particle-Induced Chromosome Aberrations in Human CD34+ Cells

RM Anderson, DL Stevens, ND Sumption… - Radiation …, 2007 - meridian.allenpress.com
Abstract Anderson, R. M, Stevens, DL, Sumption, ND, Townsend, KMS, Goodhead, DT and
Hill, MA Effect of Linear Energy Transfer (LET) on the Complexity of α-Particle-Induced …

mFISH analysis of chromosome aberrations in workers occupationally exposed to mixed radiation

NV Sotnik, SV Osovets, H Scherthan… - Radiation and …, 2014 - Springer
We performed a study on the presence of chromosome aberrations in a cohort of plutonium
workers of the Mayak production association (PA) with a mean age of 73.3±7.2 years to see …

Complex exchanges are responsible for the increased effectiveness of C-ions compared to X-rays at the first post-irradiation mitosis

R Lee, S Sommer, C Hartel, E Nasonova… - … /Genetic Toxicology and …, 2010 - Elsevier
The purpose of the present study was to investigate as to what extent differences in the
linear energy transfer (LET) are reflected at the chromosomal level. For this study human …

Function of chromatin structure and dynamics in DNA damage, repair and misrepair: γ-rays and protons in action

L Ježková, M Falk, I Falková, M Davídková… - Applied Radiation and …, 2014 - Elsevier
According to their physical characteristics, protons and ion beams promise a revolution in
cancer radiotherapy. Curing protocols however reflect rather the empirical knowledge than …

The progress of radiobiological models in modern radiotherapy with emphasis on the uncertainty issue

CKC Wang - Mutation Research/Reviews in Mutation Research, 2010 - Elsevier
Radiobiological models are used in modern radiotherapy to evaluate the biological effects of
different treatment plans or modalities. A radiobiological model typically converts a physical …