Ferroptosis is a form of regulated cell death characterized by iron-dependent lipid
peroxidation. This process contributes to cellular and tissue damage in various human …

Metformin, an oral antihyperglycemic drug that has been in use for over 60 years, remains a
first-line therapy for type 2 diabetes (T2D). Numerous studies have suggested that metformin …

Iron overload, characterized by accumulation of iron in tissues, induces a multiorgan toxicity
whose mechanisms are not fully understood. Using cultured cell lines, Caenorhabditis …

Maternal age at childbearing has continued to increase in recent decades. However,
whether and how it influences offspring adult traits are largely unknown. Here, using adult …

Abstract Exposure to N-(1, 3-dimethylbutyl)-N′-phenyl-p-phenylenediamine quinone (6-
PPDQ) caused toxicity on Caenorhabditis elegans, including reproductive toxicity. However …

Healthy mitochondria are critical for reproduction. During aging, both reproductive fitness
and mitochondrial homeostasis decline. Mitochondrial metabolism and dynamics are key …

B vitamins are intricately involved in various physiological processes vital for health. Their
significance is complicated by the heterogeneous landscape of B vitamin distribution in diets …

Vitamins are dietary components necessary for cellular metabolic balance, especially redox
homeostasis; deficient or excessive supply may give rise to symptoms of psychiatric …

Ferroptosis is programmed cell death induced by iron-driven lipid peroxidation. Numerous
studies have shown that ferroptosis is implicated in the progression of colorectal cancer …

The genome of Caenorhabditis elegans encodes 284 nuclear hormone receptor, which
perform diverse functions in development and physiology. One of the best characterized of …