Breast cancer is the most prevalent cancer among women worldwide. Among the different
breast cancer subtypes, triple-negative breast cancer (TNBC), which is more prevalent …

A major challenge in the management of breast cancer disease has been the development
of metastases. Finding new molecular targets and the design of targeted therapeutic …

Triple-negative breast cancer (TNBC) has an aggressive behavior and limited therapeutic
options due to lack of targeted therapy. We aimed in this study to assess the …

Pyruvate kinase is a key enzyme in the glycolytic pathway that converts
phosphoenolpyruvate to pyruvate, and the M2 isoform of pyruvate kinase (PKM2) is …

Estrogen receptor-positive, progesterone receptor-negative, and human epidermal growth
factor receptor 2 (HER2)-negative (ER+ PR-HER2-) breast cancer comprise a special type of …

Triple negative breast cancer (TNBC) is a heterogeneous disease and an attempt was made
to classify TNBCs into surrogate molecular subtypes using immunohistochemical markers …

Results Histopathologic subtyping of the 111 triple negative breast cancers identified 89.1%
invasive ductal carcinomas of no special type and 10.9% other special types of cancers …

Significant efforts have been made to gain a better understanding of the heterogeneity of
triple-negative breast cancers from the histological to the molecular and genomic levels. In …

Triple negative breast cancer account for 10% to 20% of all newly diagnosed breast cancer
cases, this subtype is well known for its lack of estrogen, progesterone and HER2 …

Breast cancer is one of the leading causes of death in humans worldwide and is the most
common type of cancer in women. Several factors are responsible for the development of …