Integrins as therapeutic targets in the organ-specific metastasis of human malignant melanoma

R Huang, EK Rofstad - Journal of Experimental & Clinical Cancer …, 2018 - Springer
Integrins are a large family of adhesion molecules that mediate cell-cell and cell-
extracellular matrix interactions. Among the 24 integrin isoforms, many have been found to …

Surface receptor‐mediated targeted drug delivery systems for enhanced cancer treatment: A state‐of‐the‐art review

S Kunjiappan, P Pavadai, S Vellaichamy… - Drug Development …, 2021 - Wiley Online Library
Enhanced cancer treatment remains as one of the focused areas for researchers around the
world. Hence, the progress in this direction will be a challenge and an opportunity in, inter …

[HTML][HTML] Integrin-mediated cancer progression as a specific target in clinical therapy

JR Chen, JT Zhao, ZZ Xie - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Integrins, a group of heterodimer receptors for cell-matrix and cell-cell adhesion, mediate
various intracellular activities, including cell migration, polarity, survival, growth, and death …

[HTML][HTML] Fetal and neonatal alloimmune thrombocytopenia: Current pathophysiological insights and perspectives for future diagnostics and treatment

W Stam, GE Wachholz, JM de Pereda, R Kapur… - Blood reviews, 2023 - Elsevier
FNAIT is a pregnancy-associated condition caused by maternal alloantibodies against
paternally-inherited platelet antigens, most frequently HPA-1a on integrin β3. The clinical …

CAR T cells targeting αvβ3 integrin are effective against advanced cancer in preclinical models

L Wallstabe, A Mades, S Frenz… - Advances in cell and …, 2018 - Wiley Online Library
Integrins are heterodimeric receptors that convey cell‐to‐cell and cell‐to‐matrix interactions.
Integrin αvβ3 is expressed in several tumor entities including melanoma, glioblastoma …

ANGPTL3: a novel biomarker and promising therapeutic target

S Jiang, GH Qiu, N Zhu, ZY Hu, DF Liao… - Journal of drug …, 2019 - Taylor & Francis
Abstract Angiopoietin-like protein 3 (ANGPTL3) belongs to a multifunctional secreted protein
that mainly expresses in the liver, and is regulated by numerous post-translational …

Avidity and cell uptake of integrin-targeting polypeptide micelles is strongly shape-dependent

M Dzuricky, S Xiong, P Weber, A Chilkoti - Nano letters, 2019 - ACS Publications
We describe a genetically encoded micelle for targeted delivery consisting of a diblock
polypeptide with segments derived from repetitive protein motifs inspired by Drosophila …

Role of collagen regulators in cancer treatment: A comprehensive review

T Angre, A Kumar, AK Singh, S Thareja… - Anti-Cancer Agents in …, 2022 - ingentaconnect.com
Collagen is the most important structural protein and also the main component of the extra-
cellular matrix (ECM). It plays a role in tumor progression. Collagen can be regulated by …

Insights Into Protein–Ligand Interactions in Integrin Complexes: Advances in Structure Determinations

Y Zheng, K Leftheris - Journal of Medicinal Chemistry, 2020 - ACS Publications
Integrins comprise a family of 24 heterodimeric transmembrane receptors that mediate cell
attachment to the extracellular matrix and are critical for cell signaling. There are four …

Engineering of anti-human interleukin-4 receptor alpha antibodies with potent antagonistic activity

JE Kim, K Jung, JA Kim, SH Kim, HS Park, YS Kim - Scientific reports, 2019 - nature.com
Abstract Development of antagonistic antibody (Ab) against interleukin-4 receptor alpha (IL-
4Rα) subunit of IL-4/IL-13 receptors is a promising therapeutic strategy for T helper 2 (TH2) …