Significance: The detrimental effects of ionizing radiation (IR) involve a highly orchestrated
series of events that are amplified by endogenous signaling and culminating in oxidative …

It has become increasingly difficult to find an area of cell biology in which lipids do not have
important, if not key, roles as signalling and regulatory molecules. The rapidly expanding …

Ceramide, the precursor of all complex sphingolipids, is a potent signaling molecule that
mediates key events of cellular pathophysiology. In the nervous system, the sphingolipid …

Acid sphingomyelinase occupies a prominent position in sphingolipid catabolism, catalyzing
the hydrolysis of sphingomyelin to ceramide and phosphorylcholine. Enzymatic dysfunction …

Programmed cell death, or apoptosis, is a complex process whereby eukaryotic cells react to
physiologic or pathophysiologic stimuli by undergoing genetically programmed suicide …

Abstract Acid sphingomyelinase (ASM; EC 3.1. 4.12) is best known for its involvement in the
lysosomal storage disorder Niemann-Pick disease (NPD). Through studies that began by …

Acid sphingomyelinase (ASM), a key enzyme in sphingolipid metabolism, hydrolyzes
sphingomyelin to ceramide and phosphorylcholine. In mammals, the expression of a single …

Sphingomyelinases (SMases) hydrolyse sphingomyelin, releasing ceramide and creating a
cascade of bioactive lipids. These lipids include sphingosine and sphingosine-1-phosphate …

Acid sphingomyelinase (ASM) plays an important role in normal membrane turnover through
the hydrolysis of sphingomyelin, and is one of the key enzymes responsible for the …

E vidence has consistently indicated that activation of sphingomyelinases and/or ceramide
synthases and the resulting accumulation of ceramide mediate cellular responses to …