Vitamin D signaling plays an essential role in innate defense against intracellular
microorganisms via the generation of the antimicrobial protein cathelicidin. In addition to …

Purpose Vitamin D is a fascinating and attractive molecule that has gained particular
attention in medicine in recent years. Its immunomodulatory and anti-inflammatory potential …

Regulation of immune function continues to be one of the most well recognized extraskeletal
actions of vitamin D. This stemmed initially from the discovery that antigen presenting cells …

Vitamin D is a hormone that acts on many genes expressed by immune cells. Evidence
linking vitamin D deficiency with COVID-19 severity is circumstantial but considerable—links …

Background: We aimed to establish an acute treatment protocol to increase serum vitamin D,
evaluate the effectiveness of vitamin D3 supplementation, and reveal the potential …

Platelets play a critical role in vascular inflammation through the podoplanin and
collagen/fibrin receptors, C-type-lectin-like-2 (CLEC-2) and glycoprotein VI (GPVI) …

Vitamin D induces a diverse range of biological effects, including important functions in bone
health, calcium homeostasis and, more recently, on immune function. The role of vitamin D …

The prevalence of vitamin D deficiency in intensive care units ranges typically between 40
and 70%. There are many reasons for being or becoming deficient in the ICU. Hepatic …

Sepsis is defined as the dysregulated host response to an infection resulting in life-
threatening organ dysfunction. The metabolic demand from inefficiencies in anaerobic …

Sepsis has always been considered as a big challenge for pharmaceutical companies in
terms of discovering and designing new therapeutics. The pathogenesis of sepsis involves …