Glioblastoma multiforme is the most malignant and aggressive type of brain tumor, with a
mean life expectancy of less than 15 months. This is due in part to the high resistance to …

Glioblastoma (GBM) is the most aggressive form of brain cancer, with a dismal prognosis
and extremely low percentage of survivors. Novel therapies are in dire need to improve the …

The off-target distribution of anticancer nanoparticles to fibroblasts creates a barrier to the
effective treatment of desmoplastic tumors. However, we hypothesized that this nanoparticle …

Purpose: Human neural stem cells (NSC) are inherently tumor tropic, making them attractive
drug delivery vehicles. Toward this goal, we retrovirally transduced an immortalized, clonal …

Therapeutically engineered stem cells have shown promise for glioblastoma multiforme
(GBM) therapy; however, key preclinical studies are urgently needed for their clinical …

Transdifferentiation (TD) is a recent advancement in somatic cell reprogramming. The direct
conversion of TD eliminates the pluripotent intermediate state to create cells that are ideal …

Glioblastoma is among the most aggressive and treatment resistant of all human cancers.
Conventional therapeutic approaches are unsuccessful because of diffuse infiltrative …

Engineered neural stem cells (NSCs) are a promising approach to treating glioblastoma
(GBM). The ideal NSC drug carrier for clinical use should be easily isolated and autologous …

Gliomas, which account for nearly a quarter of all primary CNS tumors, present significant
contemporary therapeutic challenges, particularly the highest-grade variant (glioblastoma …

Engineered stem cell (SC)-based therapy holds enormous promise for treating the incurable
brain cancer glioblastoma (GBM). Retaining the cytotoxic SCs in the surgical cavity after …