The S100B protein: A multifaceted pathogenic factor more than a biomarker

F Michetti, ME Clementi, R Di Liddo, F Valeriani… - International Journal of …, 2023 - mdpi.com
S100B is a calcium-binding protein mainly concentrated in astrocytes in the nervous system.
Its levels in biological fluids are recognized as a reliable biomarker of active neural distress …

Complexity in genetic epilepsies: a comprehensive review

C Rastin, LC Schenkel, B Sadikovic - International Journal of Molecular …, 2023 - mdpi.com
Epilepsy is a highly prevalent neurological disorder, affecting between 5–8 per 1000
individuals and is associated with a lifetime risk of up to 3%. In addition to high incidence …

Brain injury biomarkers and applications in neurological diseases

H Zhang, J Wang, Y Qu, Y Yang… - Chinese Medical …, 2025 - journals.lww.com
Neurological diseases are a major health concern, and brain injury is a typical pathological
process in various neurological disorders. Different biomarkers in the blood or the …

[HTML][HTML] Plasma proteomics in epilepsy: Network-based identification of proteins associated with seizures

SH Ashtiani, S Akel, E Berger, J Zelano - Epilepsy Research, 2025 - Elsevier
Purpose Identification of potential biomarkers of seizures. Methods In this exploratory study,
we quantified plasma protein intensities in 15 patients with recent seizures compared to 15 …

Diagnostic Panel of Three Genetic Biomarkers Based on Artificial Neural Network for Patients With Idiopathic Generalized Epilepsy

A Yabacı Tak, N Tak, F Ilgen Uslu… - Acta Neurologica …, 2024 - Wiley Online Library
The aim of this study is to evaluate the utility of an artificial neural network (ANN) model in
diagnosing idiopathic generalized epilepsy (IGE) and to compare the results of the …

Combined transcriptomics and proteomics forecast analysis for potential biomarker in the acute phase of temporal lobe epilepsy

C Huang, Z You, Y He, J Li, Y Liu, C Peng… - Frontiers in …, 2023 - frontiersin.org
Background Temporal lobe epilepsy (TLE) is a common chronic episodic illness of the
nervous system. However, the precise mechanisms of dysfunction and diagnostic …

Nanomedicine revolutionizes epilepsy treatment: overcoming therapeutic hurdles with nanoscale solutions

S Li, W Zhang, Y Zhu, Q Yao, R Chen… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction Epilepsy, a prevalent neurodegenerative disorder, profoundly impacts the
physical and mental well-being of millions globally. Historically, antiseizure drugs (ASDs) …

A Systematic Review of the Predictive and Diagnostic Uses of Neuroinflammation Biomarkers for Epileptogenesis

MJ Aguilar-Castillo, P Cabezudo-García… - International Journal of …, 2024 - mdpi.com
A central role for neuroinflammation in epileptogenesis has recently been suggested by
several investigations. This systematic review explores the role of inflammatory mediators in …

[HTML][HTML] Aerobic exercise alters DNA hydroxymethylation levels in an experimental rodent model of temporal lobe epilepsy

SCS Jago, R Bahabry, AM Schreiber, J Homola… - Epilepsy & Behavior …, 2024 - Elsevier
The therapeutic potential of aerobic exercise in mitigating seizures and cognitive issues in
temporal lobe epilepsy (TLE) is recognized, yet the underlying mechanisms are not well …

[HTML][HTML] High-resolution multimodal profiling of human epileptic brain activity via explanted depth electrodes

AK Dwivedi, A Mahesh, A Sanfeliu, J Larkin… - JCI …, 2025 - pmc.ncbi.nlm.nih.gov
The availability and integration of electrophysiological and molecular data from the living
brain is critical in understanding and diagnosing complex human disease. Intracranial …