[HTML][HTML] Calling in SYK: SYK's dual role as a tumor promoter and tumor suppressor in cancer

MO Krisenko, RL Geahlen - … et Biophysica Acta (BBA)-Molecular Cell …, 2015 - Elsevier
SYK (spleen tyrosine kinase) is well-characterized in the immune system as an essential
enzyme required for signaling through multiple classes of immune recognition receptors. As …

Co-expression modules construction by WGCNA and identify potential prognostic markers of uveal melanoma

Q Wan, J Tang, Y Han, D Wang - Experimental eye research, 2018 - Elsevier
Uveal melanoma is an aggressive cancer which has a high percentage recurrence and with
a worse prognosis. Identify the potential prognostic markers of uveal melanoma may provide …

Integrated proteomics and network analysis identifies protein hubs and network alterations in Alzheimer's disease

Q Zhang, C Ma, M Gearing, PG Wang, LS Chin… - Acta neuropathologica …, 2018 - Springer
Although the genetic causes for several rare, familial forms of Alzheimer's disease (AD) have
been identified, the etiology of the sporadic form of AD remains unclear. Here, we report a …

Weighted gene co-expression network analysis of endometriosis and identification of functional modules associated with its main hallmarks

MR Bakhtiarizadeh, B Hosseinpour… - Frontiers in …, 2018 - frontiersin.org
Although many genes have been identified using high throughput technologies in
endometriosis (ES), only a small number of individual genes have been analyzed …

Novel hybrid phenotype revealed in small cell lung cancer by a transcription factor network model that can explain tumor heterogeneity

AR Udyavar, DJ Wooten, M Hoeksema, M Bansal… - Cancer Research, 2017 - AACR
Small cell lung cancer (SCLC) is a devastating disease due to its propensity for early
invasion and refractory relapse after initial treatment response. Although these aggressive …

Weighted gene co-expression network analysis identifies specific modules and hub genes related to coronary artery disease

J Liu, L Jing, X Tu - BMC cardiovascular disorders, 2016 - Springer
Background The analysis of the potential molecule targets of coronary artery disease (CAD)
is critical for understanding the molecular mechanisms of disease. However, studies of …

Identification of potentially functional modules and diagnostic genes related to amyotrophic lateral sclerosis based on the WGCNA and LASSO algorithms

N Daneshafrooz, M Bagherzadeh Cham, M Majidi… - Scientific Reports, 2022 - nature.com
Amyotrophic lateral sclerosis (ALS) is a genetically and phenotypically heterogeneous
disease results in the loss of motor neurons. Mounting information points to involvement of …

Circulating tumor cells as a screening and diagnostic marker for early-stage non-small cell lung cancer

GC Duan, XP Zhang, HE Wang, ZK Wang… - OncoTargets and …, 2020 - Taylor & Francis
Background Circulating tumor cells (CTCs) have become potential diagnostic biomarker for
several types of cancer, including lung cancer. In this study, we aim to determine whether …

Identifying osteosarcoma metastasis associated genes by weighted gene co-expression network analysis (WGCNA)

H Tian, D Guan, J Li - Medicine, 2018 - journals.lww.com
Osteosarcoma (OS), the most common malignant bone tumor, accounts for the heavy
healthy threat in the period of children and adolescents. OS occurrence usually correlates …

Differential regulatory analysis based on coexpression network in cancer research

J Li, YX Li, YY Li - BioMed research international, 2016 - Wiley Online Library
With rapid development of high‐throughput techniques and accumulation of big
transcriptomic data, plenty of computational methods and algorithms such as differential …