ATP-Sensitive potassium channels and their physiological and pathophysiological roles.
ATP sensitive potassium channels (KATP) are so named because they open as cellular ATP
levels fall. This leads to membrane hyperpolarization and thus links cellular metabolism to …
levels fall. This leads to membrane hyperpolarization and thus links cellular metabolism to …
Muscle KATP Channels: Recent Insights to Energy Sensing and Myoprotection
TP Flagg, D Enkvetchakul, JC Koster… - Physiological …, 2010 - journals.physiology.org
ATP-sensitive potassium (KATP) channels are present in the surface and internal
membranes of cardiac, skeletal, and smooth muscle cells and provide a unique feedback …
membranes of cardiac, skeletal, and smooth muscle cells and provide a unique feedback …
Ventricular Fibrillation with Prominent Early Repolarization Associated with a Rare Variant of KCNJ8/KATP Channel
M Haïssaguerre, S Chatel, F Sacher… - Journal of …, 2009 - Wiley Online Library
Background: Early repolarization in the inferolateral leads has been recently recognized as
a frequent syndrome associated with idiopathic ventricular fibrillation (VF). We report the …
a frequent syndrome associated with idiopathic ventricular fibrillation (VF). We report the …
ATP-sensitive potassium channels in migraine: translational findings and therapeutic potential
Globally, migraine is a leading cause of disability with a huge impact on both the work and
private life of affected persons. To overcome the societal migraine burden, better treatment …
private life of affected persons. To overcome the societal migraine burden, better treatment …
The role of ATP‐sensitive potassium channels in cellular function and protection in the cardiovascular system
ATP‐sensitive potassium channels (KATP) are widely distributed and present in a number of
tissues including muscle, pancreatic beta cells and the brain. Their activity is regulated by …
tissues including muscle, pancreatic beta cells and the brain. Their activity is regulated by …
The ion channel and GPCR toolkit of brain capillary pericytes
Brain pericytes reside on the abluminal surface of capillaries, and their processes cover~
90% of the length of the capillary bed. These cells were first described almost 150 years ago …
90% of the length of the capillary bed. These cells were first described almost 150 years ago …
Kir6. 1 and SUR2B in Cantú syndrome
C McClenaghan, CG Nichols - American Journal of …, 2022 - journals.physiology.org
Kir6. 1 and SUR2 are subunits of ATP-sensitive potassium (KATP) channels expressed in a
wide range of tissues. Extensive study has implicated roles of these channel subunits in …
wide range of tissues. Extensive study has implicated roles of these channel subunits in …
KATP channels in lymphatic function
MJ Davis, HJ Kim, CG Nichols - American Journal of …, 2022 - journals.physiology.org
KATP channels function as negative regulators of active lymphatic pumping and lymph
transport. This review summarizes and critiques the evidence for the expression of specific …
transport. This review summarizes and critiques the evidence for the expression of specific …
Activation of cGMP-dependent protein kinase stimulates cardiac ATP-sensitive potassium channels via a ROS/calmodulin/CaMKII signaling cascade
Y Chai, DM Zhang, YF Lin - PLoS One, 2011 - journals.plos.org
Background Cyclic GMP (cGMP)-dependent protein kinase (PKG) is recognized as an
important signaling component in diverse cell types. PKG may influence the function of …
important signaling component in diverse cell types. PKG may influence the function of …
[HTML][HTML] KATP channel action in vascular tone regulation: from genetics to diseases
Abstract ATP-sensitive potassium (K ATP) channels are widely distributed in vasculatures,
and play an important role in the vascular tone regulation. The K ATP channels consist of 4 …
and play an important role in the vascular tone regulation. The K ATP channels consist of 4 …