T cell engineering has changed the landscape of cancer immunotherapy. Chimeric antigen
receptor T cells have demonstrated a remarkable efficacy in the treatment of B cell …

The T cell receptor (TCR) complex is a naturally occurring antigen sensor that detects,
amplifies and coordinates cellular immune responses to epitopes derived from cell surface …

T cell receptors (TCRs) enable T cells to specifically recognize mutations in cancer cells,–.
Here we developed a clinical-grade approach based on CRISPR–Cas9 non-viral precision …

Adoptive transfer of chimeric antigen receptor (CAR) T lymphocytes is a powerful technology
that has revolutionized the way we conceive immunotherapy. The impressive clinical results …

Precise targeting of large transgenes to T cells using homology-directed repair has been
transformative for adoptive cell therapies and T cell biology. Delivery of DNA templates via …

Natural killer (NK) cells, a unique component of the innate immune system, are inherent
killers of stressed and transformed cells. Based on their potent capacity to kill cancer cells …

T cell receptor (TCR) avidity is assumed to be a major determinant of the spatiotemporal fate
and protective capacity of tumor-specific T cells. However, monitoring polyclonal T cell …

T cell receptor (TCR)–based therapy has the potential to induce durable clinical responses
in patients with cancer by targeting intracellular tumor antigens with high sensitivity and by …

Adoptive cellular immunotherapy as a new paradigm to treat cancers is exemplified by the
FDA approval of six chimeric antigen receptor-T cell therapies targeting hematological …

Adoptive T‐cell transfer (ACT) therapies, including of tumor infiltrating lymphocytes (TILs)
and T cells gene‐modified to express either a T cell receptor (TCR) or a chimeric antigen …