Vector biology meets disease control: using basic research to fight vector-borne diseases

WR Shaw, F Catteruccia - Nature microbiology, 2019 - nature.com
Human pathogens that are transmitted by insects are a global problem, particularly those
vectored by mosquitoes; for example, malaria parasites transmitted by Anopheles species …

Mosquito innate immunity

A Kumar, P Srivastava, P Sirisena, SK Dubey, R Kumar… - Insects, 2018 - mdpi.com
Mosquitoes live under the endless threat of infections from different kinds of pathogens such
as bacteria, parasites, and viruses. The mosquito defends itself by employing both physical …

Highly evolvable malaria vectors: The genomes of 16 Anopheles mosquitoes

DE Neafsey, RM Waterhouse, MR Abai, SS Aganezov… - Science, 2015 - science.org
INTRODUCTION Control of mosquito vectors has historically proven to be an effective
means of eliminating malaria. Human malaria is transmitted only by mosquitoes in the genus …

The Plasmodium bottleneck: malaria parasite losses in the mosquito vector

RC Smith, J Vega-Rodríguez… - Memórias do Instituto …, 2014 - SciELO Brasil
Nearly one million people are killed every year by the malaria parasite Plasmodium.
Although the disease-causing forms of the parasite exist only in the human blood …

CRISPR/Cas9 -mediated gene knockout of Anopheles gambiae FREP1 suppresses malaria parasite infection

Y Dong, ML Simões, E Marois, G Dimopoulos - PLoS pathogens, 2018 - journals.plos.org
Plasmodium relies on numerous agonists during its journey through the mosquito vector,
and these agonists represent potent targets for transmission-blocking by either inhibiting or …

The Anopheles Innate Immune System in the Defense against Malaria Infection

AM Clayton, Y Dong, G Dimopoulos - Journal of innate immunity, 2014 - karger.com
The multifaceted innate immune system of insects is capable of fighting infection by a variety
of pathogens including those causing human malaria. Malaria transmission by the …

The Human Malaria Parasite Pfs47 Gene Mediates Evasion of the Mosquito Immune System

A Molina-Cruz, LS Garver, A Alabaster, L Bangiolo… - Science, 2013 - science.org
Plasmodium falciparum transmission by Anopheles gambiae mosquitoes is remarkably
efficient, resulting in a very high prevalence of human malaria infection in sub-Saharan …

Exploring Anopheles gut bacteria for Plasmodium blocking activity

AC Bahia, Y Dong, BJ Blumberg… - Environmental …, 2014 - Wiley Online Library
Malaria parasite transmission requires the successful development of P lasmodium
gametocytes into flagellated microgametes upon mosquito blood ingestion, and the …

Antiviral immunity of Anopheles gambiae is highly compartmentalized, with distinct roles for RNA interference and gut microbiota

G Carissimo, E Pondeville… - Proceedings of the …, 2015 - National Acad Sciences
Arboviruses are transmitted by mosquitoes and other arthropods to humans and animals.
The risk associated with these viruses is increasing worldwide, including new emergence in …

Mosquito immune defenses against Plasmodium infection

CM Cirimotich, Y Dong, LS Garver, S Sim… - Developmental & …, 2010 - Elsevier
The causative agent of malaria, Plasmodium, has to undergo complex developmental
transitions and survive attacks from the mosquito's innate immune system to achieve …