Autophagy-independent functions of the autophagy machinery
L Galluzzi, DR Green - Cell, 2019 - cell.com
Macroautophagy (herein referred to as autophagy) is an evolutionary ancient mechanism
that culminates with the lysosomal degradation of superfluous or potentially dangerous …
that culminates with the lysosomal degradation of superfluous or potentially dangerous …
Targeting topoisomerase I in the era of precision medicine
Irinotecan and topotecan have been widely used as anticancer drugs for the past 20 years.
Because of their selectivity as topoisomerase I (TOP1) inhibitors that trap TOP1 cleavage …
Because of their selectivity as topoisomerase I (TOP1) inhibitors that trap TOP1 cleavage …
The molecular landscape of ETMR at diagnosis and relapse
Embryonal tumours with multilayered rosettes (ETMRs) are aggressive paediatric embryonal
brain tumours with a universally poor prognosis. Here we collected 193 primary ETMRs and …
brain tumours with a universally poor prognosis. Here we collected 193 primary ETMRs and …
[HTML][HTML] MYC assembles and stimulates topoisomerases 1 and 2 in a “topoisome”
High-intensity transcription and replication supercoil DNA to levels that can impede or halt
these processes. As a potent transcription amplifier and replication accelerator, the proto …
these processes. As a potent transcription amplifier and replication accelerator, the proto …
Therapeutic strategies of dual-target small molecules to overcome drug resistance in cancer therapy
J Ye, J Wu, B Liu - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
Despite some advances in targeted therapeutics of human cancers, curative cancer
treatment still remains a tremendous challenge due to the occurrence of drug resistance. A …
treatment still remains a tremendous challenge due to the occurrence of drug resistance. A …
PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation
Abstract Poly (ADP)-ribosylation (PARylation) regulates chromatin structure and recruits
DNA repair proteins. Using single-molecule fluorescence microscopy to track topoisomerase …
DNA repair proteins. Using single-molecule fluorescence microscopy to track topoisomerase …
PARP1-dependent DNA-protein crosslink repair
Z Fábián, ES Kakulidis, IA Hendriks… - Nature …, 2024 - nature.com
DNA-protein crosslinks (DPCs) are toxic lesions that inhibit DNA related processes. Post-
translational modifications (PTMs), including SUMOylation and ubiquitylation, play a central …
translational modifications (PTMs), including SUMOylation and ubiquitylation, play a central …
[HTML][HTML] A literature review of the promising future of TROP2: A potential drug therapy target
Y Wen, D Ouyang, Q Zou, Q Chen, N Luo… - Annals of …, 2022 - ncbi.nlm.nih.gov
Methods A total of 1,376 published literatures from PubMed and 614 published literatures
from EMBASE were retrieved by searching “TROP2” or “Trophoblast cell surface antigen 2” …
from EMBASE were retrieved by searching “TROP2” or “Trophoblast cell surface antigen 2” …
Discovery and mechanistic study of tailor-made quinoline derivatives as topoisomerase 1 poison with potent anticancer activity
To overcome chemical limitations of camptothecin (CPT), we report design, synthesis, and
validation of a quinoline-based novel class of topoisomerase 1 (Top1) inhibitors and …
validation of a quinoline-based novel class of topoisomerase 1 (Top1) inhibitors and …
[HTML][HTML] The role of single strand break repair pathways in cellular responses to camptothecin induced DNA damage
C Mei, L Lei, LM Tan, XJ Xu, BM He, C Luo… - Biomedicine & …, 2020 - Elsevier
Efficient DNA repair is critical for cell survival following exposure to DNA topoisomerase I
(Top1) inhibitors camptothecin, a nature product from which the common chemotherapeutic …
(Top1) inhibitors camptothecin, a nature product from which the common chemotherapeutic …