Mechanisms of immunothrombosis and vasculopathy in antiphospholipid syndrome

JS Knight, Y Kanthi - Seminars in immunopathology, 2022 - Springer
Antiphospholipid syndrome (APS) is an autoimmune thrombophilia propelled by circulating
antiphospholipid antibodies that herald vascular thrombosis and obstetrical complications …

Coronavirus disease 2019–associated coagulopathy

G Lippi, F Sanchis-Gomar, EJ Favaloro, CJ Lavie… - Mayo Clinic …, 2021 - Elsevier
Patients with the severe form of coronavirus disease 2019 (COVID-19) have been frequently
found to suffer from both arterial and venous thrombotic events due to the perpetuation of a …

[PDF][PDF] Guidelines on the investigation and management of antiphospholipid syndrome.

D Keeling, I Mackie, GW Moore, IA Greer… - British journal of …, 2012 - academia.edu
1Oxford Haemophilia and Thrombosis Centre, Churchill Hospital, Oxford, UK, 2Haemostasis
Research Unit, Haematology Department, University College London, London, UK, 3Centre …

A novel C5a receptor-tissue factor cross-talk in neutrophils links innate immunity to coagulation pathways

K Ritis, M Doumas, D Mastellos, A Micheli… - The Journal of …, 2006 - journals.aai.org
Neutrophils and complement are key sentinels of innate immunity and mediators of acute
inflammation. Recent studies have suggested that inflammatory processes modulate …

Efficacy of the antiphospholipid score for the diagnosis of antiphospholipid syndrome and its predictive value for thrombotic events

K Otomo, T Atsumi, O Amengual, Y Fujieda… - Arthritis & …, 2012 - Wiley Online Library
Objective To define the antiphospholipid score (aPL‐S) by testing multiple antiphospholipid
antibodies (aPL) and to evaluate its efficacy for the diagnosis of antiphospholipid syndrome …

Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein

VY Bogdanov, V Balasubramanian, J Hathcock… - Nature medicine, 2003 - nature.com
Tissue factor (TF) is an essential enzyme activator that forms a catalytic complex with FVIIa
and initiates coagulation by activating FIX and FX, ultimately resulting in thrombin formation …

[HTML][HTML] Human cell-derived microparticles promote thrombus formation in vivo in a tissue factor-dependent manner

E Biro, KN Sturk-Maquelin, GMT Vogel… - Journal of Thrombosis …, 2003 - Elsevier
Background: Circulating microparticles of various cell types are present in healthy
individuals and, in varying numbers and antigenic composition, in various disease states. To …

Association of autoantibodies against the phosphatidylserine–prothrombin complex with manifestations of the antiphospholipid syndrome and with the presence of …

T Atsumi, M Ieko, ML Bertolaccini… - … : Official Journal of …, 2000 - Wiley Online Library
Objective To clarify the association of autoantibodies against prothrombin with the clinical
manifestations of the antiphospholipid syndrome (APS) and with the presence of lupus …

The antiphospholipid syndrome: from pathophysiology to treatment

S Negrini, F Pappalardo, G Murdaca, F Indiveri… - Clinical and …, 2017 - Springer
Antiphospholipid antibody syndrome (APS) is an autoimmune acquired thrombophilia
characterized by recurrent thrombosis and pregnancy morbidity in the presence of …

Anti-phospholipid syndrome and COVID-19 thrombosis: connecting the dots

ML Tung, B Tan, R Cherian… - … advances in practice, 2021 - academic.oup.com
As the coronavirus disease 2019 (COVID-19) pandemic, which is caused by the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading rapidly worldwide, it …