Tuberculosis still remains one of the most common, communicable, and leading deadliest
diseases known to mankind throughout the world. Drug-resistance in Mycobacterium …

Morpholine, a six-membered heterocycle containing one nitrogen and one oxygen atom, is a
moiety of great significance. It forms an important intermediate in many industrial and …

Oxazolidinone is a five-member heterocyclic ring with several biological applications in
medicinal chemistry. Among the three possible isomers, 2-oxazolidinone is the most …

Tuberculosis (TB) has been considered as the highly chronic, contagious and infectious
disorder caused by Mycobacterium tuberculosis (Mtb). Every year more than 10 million …

Thiophene, as a member of the group of five‐membered heterocycles containing one
heteroatom, is one of the simplest heterocyclic systems. Many synthetic strategies allow the …

We have conducted an analysis of azaspiro [3.3] heptanes used as replacements for
morpholines, piperidines, and piperazines in a medicinal chemistry context. In most cases …

A series of spiro-quinazolinone scaffolds were constructed based on the bioactivity of
quinazolinone and the inherent feature of spirocycle to design novel chitin synthase …

A low-cost, protecting group-free route to 6-(2-fluoro-4-nitrophenyl)-2-oxa-6-azaspiro [3.3]
heptane (1), the starting material for the in-development tuberculosis treatment TBI-223, is …

The human African trypanosomiasis is a devastating parasitic infection, which is caused by
the protozoan Trypanosoma brucei and transmitted by the bite of the tsetse fly. An untreated …

Herein we describe the design, synthesis and anticancer evaluation of a series of 2, 3-
dihydroimidazo [2, 1-b] thiazoles as dual kinase inhibitors of IGF1R and EGFR. A series of …