The obese adipose tissue microenvironment in cancer development and progression

DF Quail, AJ Dannenberg - Nature Reviews Endocrinology, 2019 - nature.com
Obesity is associated with both increased cancer incidence and progression in multiple
tumour types, and is estimated to contribute to up to 20% of cancer-related deaths. These …

Physical activity, sedentary behaviour, diet, and cancer: an update and emerging new evidence

J Kerr, C Anderson, SM Lippman - The Lancet Oncology, 2017 - thelancet.com
The lifestyle factors of physical activity, sedentary behaviour, and diet are increasingly being
studied for their associations with cancer. Physical activity is inversely associated with and …

Nutrition, inflammation and cancer

L Zitvogel, F Pietrocola, G Kroemer - Nature immunology, 2017 - nature.com
Quantitative and qualitative aspects of nutrition have a profound effect on leukocytes and
thereby affect proinflammatory carcinogenic effects or anticancer immune responses. As a …

Cancer, obesity, diabetes, and antidiabetic drugs: is the fog clearing?

AJ Klil-Drori, L Azoulay, MN Pollak - Nature reviews Clinical oncology, 2017 - nature.com
The prevalence of obesity, of type 2 diabetes mellitus (T2DM), and of cancer are all
increasing globally. The relationships between these diseases are complex, and thus …

Epigenome-based cancer risk prediction: rationale, opportunities and challenges

M Widschwendter, A Jones, I Evans, D Reisel… - Nature reviews Clinical …, 2018 - nature.com
The incidence of cancer is continuing to rise and risk-tailored early diagnostic and/or primary
prevention strategies are urgently required. The ideal risk-predictive test should: integrate …

Childhood obesity and cancer risk in adulthood

P Weihe, J Spielmann, H Kielstein… - Current obesity …, 2020 - Springer
Abstract Purpose of Review The purpose of this review is to summarize our current
understanding of the association between childhood obesity and cancer risk later in life …

Insights into the link between obesity and cancer

SE Ackerman, OA Blackburn, F Marchildon… - Current obesity …, 2017 - Springer
Abstract Purpose of Review Adipocytes have adapted to store energy in the form of lipid and
also secrete circulating factors called adipokines that signal to other tissues to coordinate …

Translating energy balance research from the bench to the clinic to the community: Parallel animal‐human studies in cancer

MB Garcia, KL Schadler, J Chandra… - CA: A Cancer …, 2023 - Wiley Online Library
Advances in energy balance and cancer research to date have largely occurred in siloed
work in rodents or patients. However, substantial benefit can be derived from parallel studies …

The many faces of obesity and its influence on breast cancer risk

T Agurs-Collins, SA Ross, BK Dunn - Frontiers in oncology, 2019 - frontiersin.org
Obesity is associated with increased risk of breast and other cancers. However, the
complexity of the underlying mechanisms, together with the interplay of diet and physical …

Lifestyle and host determinants of antitumor immunity and cancer health disparities

A Swaby, A Atallah, O Varol, A Cristea, DF Quail - Trends in Cancer, 2023 - cell.com
Lifestyle factors exert profound effects on host physiology and immunology. Disparities in
cancer outcomes persist as a complex and multifaceted challenge, necessitating a …