Crosstalk between oxidative stress and ferroptosis/oxytosis in ischemic stroke: possible targets and molecular mechanisms

JX Ren, C Li, XL Yan, Y Qu, Y Yang… - Oxidative Medicine and …, 2021 - Wiley Online Library
Oxidative stress is a key cause of ischemic stroke and an initiator of neuronal dysfunction
and death, mainly through the overproduction of peroxides and the depletion of antioxidants …

Mitochondria and reactive oxygen species in aging and age-related diseases

C Giorgi, S Marchi, ICM Simoes, Z Ren… - International review of …, 2018 - Elsevier
Aging has been linked to several degenerative processes that, through the accumulation of
molecular and cellular damage, can progressively lead to cell dysfunction and organ failure …

[HTML][HTML] Biological functions and regulatory mechanisms of hypoxia-inducible factor-1α in ischemic stroke

Q He, Y Ma, J Liu, D Zhang, J Ren, R Zhao… - Frontiers in …, 2021 - frontiersin.org
Ischemic stroke is caused by insufficient cerebrovascular blood and oxygen supply. It is a
major contributor to death or disability worldwide and has become a heavy societal and …

Oxygen sensing, homeostasis, and disease

GL Semenza - New England Journal of Medicine, 2011 - Mass Medical Soc
Pathways that sense a reduction in available oxygen are critical in the adaptation to lower
oxygen tensions at high altitude. Alterations in this system can contribute to the …

Guidelines for the management of spontaneous intracerebral hemorrhage: a guideline for healthcare professionals from the American Heart Association/American …

LB Morgenstern, JC Hemphill III, C Anderson, K Becker… - Stroke, 2010 - Am Heart Assoc
Purpose—The aim of this guideline is to present current and comprehensive
recommendations for the diagnosis and treatment of acute spontaneous intracerebral …

[HTML][HTML] Research on ferroptosis as a therapeutic target for the treatment of neurodegenerative diseases

Y Wang, M Lv, W Zhao - Ageing research reviews, 2023 - Elsevier
Ferroptosis is an iron-and lipid peroxidation (LPO)-mediated programmed cell death type.
Recently, mounting evidence has indicated the involvement of ferroptosis in …

Ferroptosis in neurological diseases

JX Ren, X Sun, XL Yan, ZN Guo… - Frontiers in Cellular …, 2020 - frontiersin.org
Ferroptosis is mechanism for non-apoptotic, iron-dependent, oxidative cell death that is
characterized by glutathione consumption and lipid peroxides accumulation. Ferroptosis is …

Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases

HK Eltzschig, DL Bratton, SP Colgan - Nature Reviews Drug Discovery, 2014 - nature.com
Hypoxia-inducible factors (HIFs) are stabilized during adverse inflammatory processes
associated with disorders such as inflammatory bowel disease, pathogen infection and …

The chemical biology of ferroptosis in the central nervous system

RR Ratan - Cell chemical biology, 2020 - cell.com
Over the past five decades, thanatology has come to include the study of how individual
cells in our bodies die appropriately and inappropriately in response to physiological and …

Hypoxia‐inducible factors as neuroprotective agent in Alzheimer's disease

BS Ashok, TA Ajith, S Sivanesan - Clinical and Experimental …, 2017 - Wiley Online Library
Summary Beta amyloid (Aβ)‐42 peptide and phosphorylated tau protein have been
demonstrated as the pathological hallmarks of Alzheimer's disease (AD). A gradual decline …