ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

Dementia is a rapidly rising global health crisis that silently disables families and ends lives
and livelihoods around the world. To date, however, no early biomarkers or effective …

Microglia are brain-resident immune cells with a repertoire of functions in the brain.
However, the extent of their interactions with the vasculature and potential regulation of …

Neuronal hyperactivity is a key feature of early stages of Alzheimer's disease (AD). Genetic
studies in AD support that microglia act as potential cellular drivers of disease risk, but the …

Microglia are resident immune cells in the central nervous system, playing critical roles in
brain development and homeostasis. Increasing evidence has implicated microglia …

Recently, we reported oligoadenylate synthetase 1 (OAS1) contributed to the risk of
Alzheimer's disease, by its enrichment in transcriptional networks expressed by microglia …

Increasing evidence supports the notion that neuroinflammation plays a critical role in the
etiology of major depressive disorder (MDD), at least in a subset of patients. By virtue of their …

Intercellular signaling molecules such as cytokines and their receptors enable immune cells
to communicate with one another and their surrounding microenvironments. Emerging …

Microglia are the resident immune cells of the central nervous system and are involved in
brain development, homeostasis, and disease. New imaging and genomics technologies …

Autism spectrum disorder (ASD) is a major neurodevelopmental disorder affecting 1 in 36
children in the United States. While neurons have been the focus of understanding ASD, an …