Pathogenesis of Helicobacter pylori infection

V Camilo, T Sugiyama, E Touati - Helicobacter, 2017 - Wiley Online Library
Helicobacter pylori is responsible for the most commonly found infection in the world's
population. It is the major risk factor for gastric cancer development. Numerous studies …

Helicobacter pylori Virulence Factors Exploiting Gastric Colonization and its Pathogenicity

S Ansari, Y Yamaoka - Toxins, 2019 - mdpi.com
Helicobacter pylori colonizes the gastric epithelial cells of at least half of the world's
population, and it is the strongest risk factor for developing gastric complications like chronic …

Helicobacter pylori Virulence Factor Cytotoxin-Associated Gene A (CagA)-Mediated Gastric Pathogenicity

S Ansari, Y Yamaoka - International journal of molecular sciences, 2020 - mdpi.com
Helicobacter pylori causes persistent infection in the gastric epithelium of more than half of
the world's population, leading to the development of severe complications such as peptic …

TIFA Signaling in Gastric Epithelial Cells Initiates the cag Type 4 Secretion System-Dependent Innate Immune Response to Helicobacter pylori Infection

A Gall, RG Gaudet, SD Gray-Owen, NR Salama - MBio, 2017 - Am Soc Microbiol
Helicobacter pylori is a bacterial pathogen that colonizes the human stomach, causing
inflammation which, in some cases, leads to gastric ulcers and cancer. The clinical outcome …

Helicobacter pylori modulates host cell responses by CagT4SS-dependent translocation of an intermediate metabolite of LPS inner core heptose biosynthesis

SC Stein, E Faber, SH Bats, T Murillo, Y Speidel… - PLoS …, 2017 - journals.plos.org
Highly virulent Helicobacter pylori cause proinflammatory signaling inducing the
transcriptional activation and secretion of cytokines such as IL-8 in epithelial cells …

High-resolution mapping reveals that microniches in the gastric glands control Helicobacter pylori colonization of the stomach

C Fung, S Tan, M Nakajima, EC Skoog… - PLoS …, 2019 - journals.plos.org
Lifelong infection of the gastric mucosa by Helicobacter pylori can lead to peptic ulcers and
gastric cancer. However, how the bacteria maintain chronic colonization in the face of …

Animal Models and Helicobacter pylori Infection

S Ansari, Y Yamaoka - Journal of clinical medicine, 2022 - mdpi.com
Helicobacter pylori colonize the gastric mucosa of at least half of the world's population.
Persistent infection is associated with the development of gastritis, peptic ulcer disease, and …

Antimicrobial resistance patterns and genetic elements associated with the antibiotic resistance of Helicobacter pylori strains from Shanghai

Y Liu, S Wang, F Yang, W Chi, L Ding, T Liu, F Zhu, D Ji… - Gut pathogens, 2022 - Springer
Abstract Background Shanghai, in east China, has one of the world's highest burdens of
Helicobacter pylori infection. While multidrug regimens can effectively eradicate H. pylori …

Role of the CagY antenna projection in Helicobacter pylori Cag type IV secretion system activity

SC Tran, MS McClain, TL Cover - Infection and Immunity, 2023 - Am Soc Microbiol
Helicobacter pylori strains containing the cag pathogenicity island (PAI) are associated with
the development of gastric adenocarcinoma and peptic ulcer disease. The cag PAI encodes …

The Helicobacter pylori Type IV Secretion System Encoded by the cag Pathogenicity Island: Architecture, Function, and Signaling

S Backert, R Haas, M Gerhard, M Naumann - Type IV Secretion in Gram …, 2017 - Springer
Various gram-negative pathogens express type IV secretion systems (T4SSs) which
translocate bacterial virulence factors into host target cells to hijack cellular processes for …