A fundamental goal in cancer research is to understand the mechanisms of cell
transformation. This is key to developing more efficient cancer detection methods and …

The retinoblastoma susceptibility gene (RB1) was the first tumor suppressor gene to be
molecularly defined. RB1 mutations occur in almost all familial and sporadic forms of …

The LinkedOmics database contains multi-omics data and clinical data for 32 cancer types
and a total of 11 158 patients from The Cancer Genome Atlas (TCGA) project. It is also the …

Several protein lysine methyltransferases and demethylases have been identified to have
critical roles in histone modification. A large body of evidence has indicated that their …

Hepatocellular carcinoma (HCC) typically has poor prognosis, because it is often diagnosed
at an advanced stage. Heterogeneous phenotypic and genetic traits of affected individuals …

Proteins that are related to the retinoblastoma tumour suppressor pRB and the E2F
transcription factor are conserved in many species of plants and animals. The mammalian …

Recent studies highlight the importance of the RB1 tumor suppressor as a target for cancer
therapy. Canonically, RB1 regulates cell cycle progression and represents the downstream …

Hepatocellular carcinoma (HCC) is the most common primary malignant tumor that accounts
for~ 80% of all liver cancer cases worldwide. It is a multifactorial disease caused by a variety …

Oral cancer is a sub-category of head and neck cancers that primarily initiates in the oral
cavity. The primary treatment option for oral cancer remains surgery but it is associated with …

In the absence of a dominant driving mutation other than uniformly present TP53 mutations,
deeper understanding of the biology driving ovarian high-grade serous cancer (HGSC) …