[HTML][HTML] Mesenchymal stem cell-macrophage crosstalk and maintenance of inflammatory microenvironment homeostasis

D Lu, Y Xu, Q Liu, Q Zhang - Frontiers in cell and developmental …, 2021 - frontiersin.org
Macrophages are involved in almost every aspect of biological systems and include
development, homeostasis and repair. Mesenchymal stem cells (MSCs) have good clinical …

Immunosuppressive effects of mesenchymal stem cells-derived exosomes

X Qian, N An, Y Ren, C Yang, X Zhang, L Li - Stem cell reviews and reports, 2021 - Springer
Mesenchymal stem cells (MSCs) have become important seed cells in therapy because of
their immunosuppressive function and anti-inflammatory effects. MSCs exert …

[HTML][HTML] Sotatercept analog suppresses inflammation to reverse experimental pulmonary arterial hypertension

SR Joshi, J Liu, T Bloom, E Karaca Atabay, TH Kuo… - Scientific reports, 2022 - nature.com
Sotatercept is an activin receptor type IIA-Fc (ActRIIA-Fc) fusion protein that improves
cardiopulmonary function in patients with pulmonary arterial hypertension (PAH) by …

Bronchopulmonary Dysplasia–Associated Pulmonary Hypertension: An Updated Review

A El-Saie, NP Varghese, MK Webb, N Villafranco… - Seminars in …, 2023 - Elsevier
Bronchopulmonary dysplasia (BPD) is the leading cause of chronic lung disease in infants
and the commonest complication of prematurity. Advances in respiratory and overall …

Extracellular vesicles protect the neonatal lung from hyperoxic injury through the epigenetic and transcriptomic reprogramming of myeloid cells

GR Willis, M Reis, AH Gheinani… - American Journal of …, 2021 - atsjournals.org
Rationale: Mesenchymal stem/stromal cell (MSC)–small extracellular vesicle (MEx)
treatment has shown promise in experimental models of neonatal lung injury. The molecular …

Mesenchymal stromal cell-derived small extracellular vesicles restore lung architecture and improve exercise capacity in a model of neonatal hyperoxia-induced lung …

GR Willis, A Fernandez-Gonzalez, M Reis… - Journal of …, 2020 - Taylor & Francis
Early administration of mesenchymal stromal cell (MSC)-derived small extracellular vesicles
(MEx) has shown considerable promise in experimental models of bronchopulmonary …

Mesenchymal stem cell extracellular vesicles reverse sugen/hypoxia pulmonary hypertension in rats

JR Klinger, M Pereira, M Del Tatto… - American Journal of …, 2020 - atsjournals.org
Mesenchymal stem cell extracellular vesicles attenuate pulmonary hypertension, but their
ability to reverse established disease in larger animal models and the duration and …

[HTML][HTML] Role of mesenchymal stem cells and their paracrine mediators in macrophage polarization: an approach to reduce inflammation in osteoarthritis

SS Kuppa, HK Kim, JY Kang, SC Lee… - International Journal of …, 2022 - mdpi.com
Osteoarthritis (OA) is a low-grade inflammatory disorder of the joints that causes
deterioration of the cartilage, bone remodeling, formation of osteophytes, meniscal damage …

[HTML][HTML] Mesenchymal stem cell-derived small extracellular vesicles in the treatment of human diseases: Progress and prospect

J Shi, YC Zhao, ZF Niu, HJ Fan, SK Hou… - World journal of stem …, 2021 - ncbi.nlm.nih.gov
Mesenchymal stem cells (MSCs) are self-renewing, multipotent cells that could differentiate
into multiple tissues. MSC-based therapy has become an attractive and promising strategy …

[HTML][HTML] Molecular crosstalk between macrophages and mesenchymal stromal cells

HY Stevens, AC Bowles, C Yeago… - Frontiers in cell and …, 2020 - frontiersin.org
Mesenchymal stromal cells (MSCs) have been widely investigated for regenerative
medicine applications, from treating various inflammatory diseases as a cell therapy to …