Errors occurring during DNA replication can result in inaccurate replication, incomplete
replication, or re-replication, resulting in genome instability that can lead to diseases such as …

Proliferation is a key hallmark of cancer, but whether it differs between evolutionarily distinct
clones co-existing within a tumor is unknown. We introduce the Single-cell Proliferation Rate …

Faithful DNA replication is essential for genome integrity,,–. Under-replicated DNA leads to
defects in chromosome segregation, which are common during embryogenesis,,–. However …

Chromosome-wide late replication is an enigmatic hallmark of the inactive X chromosome
(Xi). How it is established and what it represents remains obscure. By single-cell DNA …

Prostate cancer aggressiveness and metastatic potential are influenced by gene expression
and genomic aberrations, features that can be influenced by the 3D structure of …

The timing of DNA replication in mammals is crucial for minimizing errors and influenced by
genome usage and chromatin states. Replication timing in the newly formed mammalian …

The placenta is a highly evolved, specialized organ in mammals. It differs from other organs
in that it functions only for fetal maintenance during gestation. Therefore, there must be …

Replication timing (RT) is a cellular program to coordinate initiation of DNA replication in all
origins within the genome. RIF1 (replication timing regulatory factor 1) is a master regulator …

DNA replication in differentiated cells follows a defined program, but when and how it is
established during mammalian development is not known. Here we show using single-cell …

The organisation of chromatin is closely intertwined with biological activities of chromosome
domains, including transcription and DNA replication status. Scaffold-attachment factor A …