In the quest for histone deacetylase inhibitors: Current trends in the application of multilayered computational methods
Histone deacetylase (HDAC) inhibitors have gained attention over the past three decades
because of their potential in the treatment of different diseases including various forms of …
because of their potential in the treatment of different diseases including various forms of …
Histone deacetylase 10, a potential epigenetic target for therapy
F Cheng, B Zheng, J Wang, G Zhao, Z Yao… - Bioscience …, 2021 - portlandpress.com
Abstract Histone deacetylase (HDAC) 10, a class II family, has been implicated in various
tumors and non-tumor diseases, which makes the discovery of biological functions and …
tumors and non-tumor diseases, which makes the discovery of biological functions and …
[HTML][HTML] The HDAC10 instructs macrophage M2 program via deacetylation of STAT3 and promotes allergic airway inflammation
Y Zhong, T Huang, J Huang, J Quan, G Su, Z Xiong… - Theranostics, 2023 - ncbi.nlm.nih.gov
Background: Perturbation of macrophage homeostasis is one of the key mechanisms of
airway inflammation in asthma. However, the exact mechanisms remain poorly understood …
airway inflammation in asthma. However, the exact mechanisms remain poorly understood …
[HTML][HTML] Characterization of the binding interaction between atrazine and human serum albumin: Fluorescence spectroscopy, molecular dynamics and quantum …
VLB França, JL Amaral, YA Martins… - Chemico-Biological …, 2022 - Elsevier
Atrazine (ATR), one of the most used herbicides worldwide, causes persistent contamination
of water and soil due to its high resistance to degradation. ATR is associated with low fertility …
of water and soil due to its high resistance to degradation. ATR is associated with low fertility …
First fluorescent acetylspermidine deacetylation assay for HDAC10 identifies selective inhibitors with cellular target engagement
D Herp, J Ridinger, D Robaa, SA Shinsky… - …, 2022 - Wiley Online Library
Histone deacetylases (HDACs) are important epigenetic regulators involved in many
diseases, especially cancer. Five HDAC inhibitors have been approved for anticancer …
diseases, especially cancer. Five HDAC inhibitors have been approved for anticancer …
Distribution and diversity of classical deacylases in bacteria
LG Graf, C Moreno-Yruela, C Qin, S Schulze… - Nature …, 2024 - nature.com
Abstract Classical Zn2+-dependent deac (et) ylases play fundamental regulatory roles in life
and are well characterized in eukaryotes regarding their structures, substrates and …
and are well characterized in eukaryotes regarding their structures, substrates and …
Exploring structural requirements of HDAC10 inhibitors through comparative machine learning approaches
Histone deacetylase (HDAC) inhibitors are in the limelight of anticancer drug development
and research. HDAC10 is one of the class-IIb HDACs, responsible for cancer progression …
and research. HDAC10 is one of the class-IIb HDACs, responsible for cancer progression …
Phenolic compounds as potential adenosine deaminase inhibitors: molecular docking and dynamics simulation coupled with MM-GBSA calculations
Adenosine deaminase (ADA) is a Zn2+-containing enzyme that catalyzes the irreversible
deamination of adenosine to inosine or deoxyadenosine to deoxyinosine. In addition to this …
deamination of adenosine to inosine or deoxyadenosine to deoxyinosine. In addition to this …
Identification of potential inhibitors of human methionine aminopeptidase (type II) for cancer therapy: Structure-based virtual screening, ADMET prediction and …
Abstract Methionine Aminopeptidases MetAPs are divalent-cofactor dependent enzymes
that are responsible for the cleavage of the initiator Methionine from the nascent …
that are responsible for the cleavage of the initiator Methionine from the nascent …
Homology modeling and in silico design of novel and potential dual-acting inhibitors of human histone deacetylases HDAC5 and HDAC9 isozymes
AD Elmezayen, K Yelekçi - Journal of Biomolecular Structure and …, 2021 - Taylor & Francis
Histone deacetylases (HDACs) are a group of enzymes that have prominent and crucial
effect on various biological systems, mainly by their suppressive effect on transcription …
effect on various biological systems, mainly by their suppressive effect on transcription …