Biocatalysis has become an important aspect of modern organic synthesis, both in
academia and across the chemical and pharmaceutical industries. Its success has been …

Proteins are nature's primary building blocks for the construction of sophisticated molecular
machines and dynamic materials, ranging from protein complexes such as photosystem II …

Developing artificial enzymes with the excellent catalytic performance of natural enzymes
has been a long-standing goal for chemists. Single-atom catalysts with well-defined atomic …

As a rising generation of nanozymes, single atom enzymes show significant promise for
cancer therapy, due to their maximum atom utilization efficiency and well-defined electronic …

Enzyme turnover numbers (k cat) are key to understanding cellular metabolism, proteome
allocation and physiological diversity, but experimentally measured k cat data are sparse …

Prediction of enzyme kinetic parameters is essential for designing and optimizing enzymes
for various biotechnological and industrial applications, but the limited performance of …

Hepatocytes operate in highly structured repeating anatomical units termed liver lobules.
Blood flow along the lobule radial axis creates gradients of oxygen, nutrients and hormones …

Anthocyanins are ubiquitous plant pigments used in a variety of technological applications.
Yet, after over a century of research, the penultimate biosynthetic step to anthocyanidins …

In the early 2000s, Tawfik presented his 'New View'on enzyme evolution, highlighting the
role of conformational plasticity in expanding the functional diversity of limited repertoires of …

Genome‐scale metabolic models (GEM s) are widely used to calculate metabolic
phenotypes. They rely on defining a set of constraints, the most common of which is that the …