The process of cancer metastasis is sequential and selective and contains stochastic
elements. The growth of metastases represents the endpoint of many lethal events that few …

Wnt signaling plays an important role in development and disease. In this review we focus
on the role of the canonical Wnt signaling pathway in somatic stem cell biology and its …

Previous studies have demonstrated that a small subset of cancer cells is capable of tumor
initiation. The existence of tumor initiating cancer stem cells (CSCs) has several implications …

The promise of human embryonic stem cell (hESC) lines for treating injuries and
degenerative diseases, for understanding early human development, for disease modelling …

Cancer stem cells (CSCs) have recently been documented in solid tumours. Evidence has
suggested that CSCs are involved in carcinogenesis, tumour invasion and metastases, and …

Human embryonic stem cells (hESCs) are of immense interest in regenerative medicine as
they can self-renew indefinitely and can give rise to any adult cell type. Human embryonal …

Cellular mechanisms of multidrug resistance (MDR) are related to ABC transporters,
apoptosis, antioxidation, drug metabolism, DNA repair and cell proliferation. It remains …

Neuroblastoma (NB) is the most common extracranial solid tumor often diagnosed in
childhood. Despite intense efforts to develop a successful treatment, current available …

The effects of trans-fatty acids (TFAs) on cardiovascular disorders have been extensively
studied, and the effect of TFAs on cancers has recently been recognized. This study …

In breast cancer it is never the primary tumour that is fatal; instead it is the development of
metastatic disease which is the major cause of cancer related mortality. There is …