Understanding the mechanisms by which chromatin structure controls eukaryotic
transcription has been an intense area of investigation for the past 25 years. Many of the key …

The many factors that control chromatin biology play key roles in essential nuclear functions
like transcription, DNA damage response and repair, recombination, and replication and are …

Translation of problematic sequences in mRNAs leads to ribosome collisions that trigger a
series of quality control events including ribosome rescue, degradation of the stalled …

All eukaryotic cells divide a finite number of times, although the mechanistic basis of this
replicative aging remains unclear. Replicative aging is accompanied by a reduction in …

Key protein adapters couple translation to mRNA decay on specific classes of problematic
mRNAs in eukaryotes. Slow decoding on non-optimal codons leads to codon-optimality …

The dimorphic switch from a single-cell budding yeast to a filamentous form enables
Saccharomyces cerevisiae to forage for nutrients and the opportunistic pathogen Candida …

A genetic interaction occurs when the combination of two mutations leads to an unexpected
phenotype. Screens for synthetic genetic interactions have been used extensively to identify …

Packaging of eukaryotic genomes into chromatin has wide-ranging effects on gene
transcription. Curiously, it is commonly observed that deletion of a global chromatin …

Our genetic information is tightly packaged into a rather ingenious nucleoprotein complex
called chromatin in a manner that enables it to be rapidly accessed during genomic …

Histone proteins often come in different variants serving specialized functions in addition to
their fundamental role in packaging DNA. The metazoan histone H3. 3 has been most …