Increased body weight and metabolic disorder including insulin resistance, type 2 diabetes
and cardiovascular complications together constitute metabolic syndrome. The …

Adipocytes are the main constituent of adipose tissue and are considered to be a corner
stone in the homeostatic control of whole body metabolism. Their primary function is to …

Excessive caloric intake without a rise in energy expenditure promotes adipocyte
hyperplasia and adiposity. The rise in adipocyte number is triggered by signaling factors that …

A mechanistic understanding of how mitochondrial dysfunction contributes to cell growth
and tumorigenesis is emerging beyond Warburg as an area of research that is under …

Mutations of the retinoblastoma tumour suppressor gene (RB1) or components regulating
the RB pathway have been identified in almost every human malignancy. The E2F …

A detailed understanding of the processes governing adipose tissue formation will be
instrumental in combating the obesity epidemic. Much progress has been made in the last …

Calorie restriction extends lifespan in organisms ranging from yeast to mammals. In yeast,
the SIR2 gene mediates the life-extending effects of calorie restriction. Here we show that …

During the last decades, research on adipose tissues has spread in parallel with the
extension of obesity. Several observations converged on the idea that adipose tissues are …

The obesity epidemic has focused attention on adipose tissue and the development of fat
cells (ie adipocytes), which is known as adipogenesis. Peroxisome proliferator-activated …

Peroxisome proliferator-activated receptors (PPARs) compose a family of three nuclear
receptors which act as lipid sensors to modulate gene expression. As such, PPARs are …