Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety

MA Hannan, MA Rahman, AAM Sohag, MJ Uddin… - Nutrients, 2021 - mdpi.com
Mounting evidence support the potential benefits of functional foods or nutraceuticals for
human health and diseases. Black cumin (Nigella sativa L.), a highly valued nutraceutical …

Ferroptosis‐modulating small molecules for targeting drug‐resistant cancer: Challenges and opportunities in manipulating redox signaling

SC Koeberle, AP Kipp, H Stuppner… - Medicinal Research …, 2023 - Wiley Online Library
Ferroptosis is an iron‐dependent cell death program that is characterized by excessive lipid
peroxidation. Triggering ferroptosis has been proposed as a promising strategy to fight …

Recent advances in understanding Nrf2 agonism and its potential clinical application to metabolic and inflammatory diseases

MJ Kim, JH Jeon - International Journal of Molecular Sciences, 2022 - mdpi.com
Oxidative stress is a major component of cell damage and cell fat, and as such, it occupies a
central position in the pathogenesis of metabolic disease. Nuclear factor-erythroid-derived 2 …

Protective Effects of Black Cumin (Nigella sativa) and Its Bioactive Constituent, Thymoquinone against Kidney Injury: An Aspect on Pharmacological Insights

MA Hannan, MS Zahan, PP Sarker, A Moni… - International Journal of …, 2021 - mdpi.com
The prevalence of chronic kidney disease (CKD) is increasing worldwide, and a close
association between acute kidney injury (AKI) and CKD has recently been identified. Black …

Mitochondrial dysfunction and oxidative stress: Role in chronic kidney disease

A Srivastava, B Tomar, D Sharma, SK Rath - Life Sciences, 2023 - Elsevier
Chronic kidney disease (CKD) is associated with a variety of distinct disease processes that
permanently change the function and structure of the kidney across months or years. CKD is …

Cellular senescence of renal tubular epithelial cells in renal fibrosis

JQ Zhang, YY Li, XY Zhang, ZH Tian, C Liu… - Frontiers in …, 2023 - frontiersin.org
Renal fibrosis (RF) is the common pathological manifestation of virtually all chronic kidney
diseases (CKD) and one of the major causes of end-stage renal disease (ESRD), but the …

Effective dose/duration of natural flavonoid quercetin for treatment of diabetic nephropathy: A systematic review and meta-analysis of rodent data

Z Li, H Deng, X Guo, S Yan, C Lu, Z Zhao, X Feng, Q Li… - Phytomedicine, 2022 - Elsevier
Background Given the challenges on diabetic nephropathy (DN) treatment, research has
been carried out progressively focusing on dietary nutrition and natural products as a novel …

Potentials of natural antioxidants in reducing inflammation and oxidative stress in chronic kidney disease

OYA Lee, ANN Wong, CY Ho, KW Tse, AZ Chan… - Antioxidants, 2024 - mdpi.com
Chronic kidney disease (CKD) presents a substantial global public health challenge, with
high morbidity and mortality. CKD patients often experience dyslipidaemia and poor …

Molecular pharmacology and therapeutic advances of the pentacyclic triterpene lupeol

AAM Sohag, MT Hossain, MA Rahaman, P Rahman… - Phytomedicine, 2022 - Elsevier
Background Plant triterpenoids are major sources of nutraceuticals that provide many health
benefits to humans. Lupeol is one of the pentacyclic dietary triterpenoids commonly found in …

Prospects for Protective Potential of Moringa oleifera against Kidney Diseases

T Akter, MA Rahman, A Moni, MAI Apu, A Fariha… - Plants, 2021 - mdpi.com
Kidney diseases are regarded as one of the major public health issues in the world. The
objectives of this study were:(i) to investigate the causative factors involved in kidney …